Efficient dose-response finding strategies for acute neuroemergency treatments

Tom Parke; Michael Krams; Peter Mueller; Don Berry

doi:10.1016/B978-012648082-5/50012-5

Efficient dose-response finding strategies for acute neuroemergency treatments

Tom Parke, Michael Krams, Peter Mueller, Don Berry

Biostatistics

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The objective of this chapter is to make a case for simulation-guided clinical trial design. It discusses the concept of adaptive dose-response finding studies with real-time learning about the research question, continuously updating the choice of treatment, and assessing whether to continue or terminate the trial. The most important result from clinical trial simulation is to give a realistic expectation of the likelihood of success of the trial. The chapter discusses a software package that allows both the simulation and the conduct of a real-time learning trial. It also presents an example of developing a neuroprotective treatment for acute ischemic stroke to develop the ideas on simulation-guided clinical trial design.

Original language	English (US)
Title of host publication	Handbook of Neuroemergency Clinical Trials
Publisher	Elsevier Inc.
Pages	179-204
Number of pages	26
ISBN (Print)	9780126480825
DOIs	https://doi.org/10.1016/B978-012648082-5/50012-5
State	Published - 2006

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/B978-012648082-5/50012-5

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PB - Elsevier Inc.

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Efficient dose-response finding strategies for acute neuroemergency treatments

Abstract

ASJC Scopus subject areas

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