Eicosanoid profiling in colon cancer: Emergence of a pattern

Xiangsheng Zuo; Imad Shureiqi

doi:10.1016/j.prostaglandins.2012.08.004

Eicosanoid profiling in colon cancer: Emergence of a pattern

Xiangsheng Zuo, Imad Shureiqi

GI Medical Oncology

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Oxidative metabolism of polyunsaturated fatty acids has been linked to tumorigenesis in general and colonic tumorigenesis in particular. Earlier studies showed that cyclooxygenase-2 (COX-2) and 15-lipoxygenase-1 (15-LOX-1) have opposing impacts on colonic tumorigenesis: COX-2 promotes while 15-LOX-1 inhibits colonic tumorigenesis. Advances in liquid chromatography/mass spectrometry have allowed for measurement of various products of oxidative metabolism in a single colonic biopsy specimen. Studies of LOX products in preclinical models and in patients with familial adenomatous polyposis and sporadic colorectal tumorigenesis indicate that LOX pathways are shifted during colonic tumorigenesis and that the main shift is downregulation of 15-LOX-1. This shift occurs during the polyp formation stage and thus offers the opportunity to modulate tumorigenesis early by correcting 15-LOX-1 downregulation.

Original language	English (US)
Pages (from-to)	139-143
Number of pages	5
Journal	Prostaglandins and Other Lipid Mediators
Volume	104-105
DOIs	https://doi.org/10.1016/j.prostaglandins.2012.08.004
State	Published - Jul 2013

Keywords

15-LOX-1
Colon cancer
Cyclooxygenases
Eicosanoid profiling
Lipoxygenases

ASJC Scopus subject areas

Biochemistry
Physiology
Pharmacology
Cell Biology

Access to Document

10.1016/j.prostaglandins.2012.08.004

Cite this

@article{f86759e5c1b247ba9c7c88df4eb64f46,

title = "Eicosanoid profiling in colon cancer: Emergence of a pattern",

abstract = "Oxidative metabolism of polyunsaturated fatty acids has been linked to tumorigenesis in general and colonic tumorigenesis in particular. Earlier studies showed that cyclooxygenase-2 (COX-2) and 15-lipoxygenase-1 (15-LOX-1) have opposing impacts on colonic tumorigenesis: COX-2 promotes while 15-LOX-1 inhibits colonic tumorigenesis. Advances in liquid chromatography/mass spectrometry have allowed for measurement of various products of oxidative metabolism in a single colonic biopsy specimen. Studies of LOX products in preclinical models and in patients with familial adenomatous polyposis and sporadic colorectal tumorigenesis indicate that LOX pathways are shifted during colonic tumorigenesis and that the main shift is downregulation of 15-LOX-1. This shift occurs during the polyp formation stage and thus offers the opportunity to modulate tumorigenesis early by correcting 15-LOX-1 downregulation.",

keywords = "15-LOX-1, Colon cancer, Cyclooxygenases, Eicosanoid profiling, Lipoxygenases",

author = "Xiangsheng Zuo and Imad Shureiqi",

note = "Funding Information: This work was partially supported by the National Cancer Institute through grant R01-CA137213 to I.S. The University of Texas MD Anderson Cancer Center is supported in part by the National Institutes of Health through Cancer Center Support Grant CA016672 .",

year = "2013",

month = jul,

doi = "10.1016/j.prostaglandins.2012.08.004",

language = "English (US)",

volume = "104-105",

pages = "139--143",

journal = "Prostaglandins and Other Lipid Mediators",

issn = "1098-8823",

publisher = "Elsevier BV",

}

TY - JOUR

T1 - Eicosanoid profiling in colon cancer

T2 - Emergence of a pattern

AU - Zuo, Xiangsheng

AU - Shureiqi, Imad

N1 - Funding Information: This work was partially supported by the National Cancer Institute through grant R01-CA137213 to I.S. The University of Texas MD Anderson Cancer Center is supported in part by the National Institutes of Health through Cancer Center Support Grant CA016672 .

PY - 2013/7

Y1 - 2013/7

N2 - Oxidative metabolism of polyunsaturated fatty acids has been linked to tumorigenesis in general and colonic tumorigenesis in particular. Earlier studies showed that cyclooxygenase-2 (COX-2) and 15-lipoxygenase-1 (15-LOX-1) have opposing impacts on colonic tumorigenesis: COX-2 promotes while 15-LOX-1 inhibits colonic tumorigenesis. Advances in liquid chromatography/mass spectrometry have allowed for measurement of various products of oxidative metabolism in a single colonic biopsy specimen. Studies of LOX products in preclinical models and in patients with familial adenomatous polyposis and sporadic colorectal tumorigenesis indicate that LOX pathways are shifted during colonic tumorigenesis and that the main shift is downregulation of 15-LOX-1. This shift occurs during the polyp formation stage and thus offers the opportunity to modulate tumorigenesis early by correcting 15-LOX-1 downregulation.

AB - Oxidative metabolism of polyunsaturated fatty acids has been linked to tumorigenesis in general and colonic tumorigenesis in particular. Earlier studies showed that cyclooxygenase-2 (COX-2) and 15-lipoxygenase-1 (15-LOX-1) have opposing impacts on colonic tumorigenesis: COX-2 promotes while 15-LOX-1 inhibits colonic tumorigenesis. Advances in liquid chromatography/mass spectrometry have allowed for measurement of various products of oxidative metabolism in a single colonic biopsy specimen. Studies of LOX products in preclinical models and in patients with familial adenomatous polyposis and sporadic colorectal tumorigenesis indicate that LOX pathways are shifted during colonic tumorigenesis and that the main shift is downregulation of 15-LOX-1. This shift occurs during the polyp formation stage and thus offers the opportunity to modulate tumorigenesis early by correcting 15-LOX-1 downregulation.

KW - 15-LOX-1

KW - Colon cancer

KW - Cyclooxygenases

KW - Eicosanoid profiling

KW - Lipoxygenases

UR - http://www.scopus.com/inward/record.url?scp=84879695167&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84879695167&partnerID=8YFLogxK

U2 - 10.1016/j.prostaglandins.2012.08.004

DO - 10.1016/j.prostaglandins.2012.08.004

M3 - Article

C2 - 22960430

AN - SCOPUS:84879695167

SN - 1098-8823

VL - 104-105

SP - 139

EP - 143

JO - Prostaglandins and Other Lipid Mediators

JF - Prostaglandins and Other Lipid Mediators

ER -

Eicosanoid profiling in colon cancer: Emergence of a pattern

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this