TY - JOUR
T1 - Electrical impedance scanning as a new breast cancer risk stratification tool for young women
AU - Stojadinovic, Alexander
AU - Nissan, Aviram
AU - Shriver, Craig D.
AU - Mittendorf, Elizabeth A.
AU - Akin, Mark D.
AU - Dickerson, Vivian
AU - Lenington, Sarah
AU - Platt, Lawrence D.
AU - Stavros, Thomas
AU - Goldstein, Steven R.
AU - Moskovitz, Orah
AU - Gallimidi, Zahava
AU - Fields, Scott I.
AU - Yeshaya, Arieh
AU - Allweis, Tanir M.
AU - Manassa, Raymond
AU - Pappo, Itzhak
AU - Ginor, Ron X.
AU - D'Agostino, Ralph B.
AU - Gur, David
PY - 2008/1/1
Y1 - 2008/1/1
N2 - Background: Electrical impedance scanning (EIS) measures changes in breast tissue associated with breast cancer (Br-Ca) development. The T-Scan(tm2000 (ED is designed to use EIS to identify women ages 30-39 with elevated risk of breast cancer (i.e., T-Scan+ women). Aim: To estimate the relative probability of breast cancer in a T-Scan+ woman compared to a randomly selected young woman. Methods: A prospective, two-cohort trial was conducted in pre-menopausal women. The Specificity (Sp)-Cohort evaluated T-Scan specificity in 1,751 asymptomatic women ages 30-39. The Sensitivity)Sn)-Cohort evaluated T-Scan sensitivity in 390 women ages 45-30 scheduled for biopsy. Specificity, sensitivity, and conservative estimate of disease prevalence were used to calculate relative probability. Results: In the Sp-Cohort, 93 of 1,751 women were T-Scan+ (Sp = 94.7%; 95% CI: 93.7-95.7%). In the Sn-Cohort, 23 of 87 biopsy-proven cancers were T-Scan+ (Sn = 26.4%; 95% CI: 17.4-35.4%). Given Sp = 94.7%, Sn = 26.4% and prevalence of 1.5 cancers/1,000 women (ages 30-39), the relative probability of a T-Scan+ woman having Br-Ca is 4.95: (95% CI: 3.16-7.14). Conclusion: EIS can identify a subset of young women with a relative probability of breast cancer almost five times greater than in the population of young women at-large. T-Scan+ women have a sufficiently high risk of Br-Ca to warrant further surveillance or imaging.
AB - Background: Electrical impedance scanning (EIS) measures changes in breast tissue associated with breast cancer (Br-Ca) development. The T-Scan(tm2000 (ED is designed to use EIS to identify women ages 30-39 with elevated risk of breast cancer (i.e., T-Scan+ women). Aim: To estimate the relative probability of breast cancer in a T-Scan+ woman compared to a randomly selected young woman. Methods: A prospective, two-cohort trial was conducted in pre-menopausal women. The Specificity (Sp)-Cohort evaluated T-Scan specificity in 1,751 asymptomatic women ages 30-39. The Sensitivity)Sn)-Cohort evaluated T-Scan sensitivity in 390 women ages 45-30 scheduled for biopsy. Specificity, sensitivity, and conservative estimate of disease prevalence were used to calculate relative probability. Results: In the Sp-Cohort, 93 of 1,751 women were T-Scan+ (Sp = 94.7%; 95% CI: 93.7-95.7%). In the Sn-Cohort, 23 of 87 biopsy-proven cancers were T-Scan+ (Sn = 26.4%; 95% CI: 17.4-35.4%). Given Sp = 94.7%, Sn = 26.4% and prevalence of 1.5 cancers/1,000 women (ages 30-39), the relative probability of a T-Scan+ woman having Br-Ca is 4.95: (95% CI: 3.16-7.14). Conclusion: EIS can identify a subset of young women with a relative probability of breast cancer almost five times greater than in the population of young women at-large. T-Scan+ women have a sufficiently high risk of Br-Ca to warrant further surveillance or imaging.
KW - Breast cancer
KW - Electrical impedance
KW - Screening
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U2 - 10.1002/jso.20931
DO - 10.1002/jso.20931
M3 - Article
C2 - 18050282
AN - SCOPUS:38649118510
SN - 0022-4790
VL - 97
SP - 112
EP - 120
JO - Journal of surgical oncology
JF - Journal of surgical oncology
IS - 2
ER -