TY - JOUR
T1 - Electrocardiographic changes after adriamycin chemotherapy
AU - Ali, M. Khalil
AU - Soto P., Alejandro
AU - Maroongroge, David
AU - Bekheit‐Saad, Soad
AU - Buzdar, Aman U.
AU - Blumenschein, George R.
AU - Hortobagyi, Gabriel N.
AU - Tashima, Charles K.
AU - Wiseman, Charles L.
AU - Shullenberger, C. C.
PY - 1979/2
Y1 - 1979/2
N2 - The electrocardiograms of 146 patients with metastatic carcinoma of the breast were reviewed before, during, and after the patients received Adriamycin (Doxorubicin) chemotherapy (AD). The most significant electrocardiographic change occurred in the amplitude of the QRS voltage. Seven patients developed cardiomyopathy after AD and showed a significant decrease in QRS voltage. This decrease, however, was more severe at the onset of congestive heart failure than at conclusion of Adriamycin. In 35 patients with pleural effusion, there was an inverse relation between the extent of the effusion and the amplitude of QRS voltage in the absence of congestive heart failure. These results indicate that 1) the sudden and relatively severe decrease in QRS voltage with the onset of CHF limits the value of this ECG criterion for predicting early Adriamycin toxicity, and 2) caution should be exercised in the interpretation of QRS voltage changes in patients with significant pleural effusion. Cancer 43:465–471, 1979.
AB - The electrocardiograms of 146 patients with metastatic carcinoma of the breast were reviewed before, during, and after the patients received Adriamycin (Doxorubicin) chemotherapy (AD). The most significant electrocardiographic change occurred in the amplitude of the QRS voltage. Seven patients developed cardiomyopathy after AD and showed a significant decrease in QRS voltage. This decrease, however, was more severe at the onset of congestive heart failure than at conclusion of Adriamycin. In 35 patients with pleural effusion, there was an inverse relation between the extent of the effusion and the amplitude of QRS voltage in the absence of congestive heart failure. These results indicate that 1) the sudden and relatively severe decrease in QRS voltage with the onset of CHF limits the value of this ECG criterion for predicting early Adriamycin toxicity, and 2) caution should be exercised in the interpretation of QRS voltage changes in patients with significant pleural effusion. Cancer 43:465–471, 1979.
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U2 - 10.1002/1097-0142(197902)43:2<465::AID-CNCR2820430210>3.0.CO;2-R
DO - 10.1002/1097-0142(197902)43:2<465::AID-CNCR2820430210>3.0.CO;2-R
M3 - Article
C2 - 421174
AN - SCOPUS:0018383627
SN - 0008-543X
VL - 43
SP - 465
EP - 471
JO - Cancer
JF - Cancer
IS - 2
ER -