Electrophysiological evidence of the neurotoxic effects of apamin on auditory function in the rat

Bartlett D. Moore; Massako Kadekaro; Howard E. Gary; Howard M. Eisenberg

doi:10.1016/0304-3940(88)90688-X

Electrophysiological evidence of the neurotoxic effects of apamin on auditory function in the rat

Bartlett D. Moore, Massako Kadekaro, Howard E. Gary, Howard M. Eisenberg

Pediatrics

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Abstract

Brainstem auditory evoked potentials (BAEPs) were recorded from rats before and after injection with apamin, a polypeptide component of bee venom. Increased absolute and interpeak latencies were found in Peaks III-VII of the BAEP beginning about 30 minutes after apamin injection suggesting impaired auditory function. No change in BAEP was found when animals were injected with saline or during the baseline period before apamin administration. Results corroborate recent findings from our laboratories of decreased glucose metabolism in brainstem nuclei of the auditory system [3] after injection with the same dose of apamin.

Original language	English (US)
Pages (from-to)	247-252
Number of pages	6
Journal	Neuroscience Letters
Volume	91
Issue number	3
DOIs	https://doi.org/10.1016/0304-3940(88)90688-X
State	Published - Sep 12 1988

Keywords

Auditory evoked potential
Bee venom
Brainstem
Neurotoxin
Rat

ASJC Scopus subject areas

General Neuroscience

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10.1016/0304-3940(88)90688-X

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title = "Electrophysiological evidence of the neurotoxic effects of apamin on auditory function in the rat",

abstract = "Brainstem auditory evoked potentials (BAEPs) were recorded from rats before and after injection with apamin, a polypeptide component of bee venom. Increased absolute and interpeak latencies were found in Peaks III-VII of the BAEP beginning about 30 minutes after apamin injection suggesting impaired auditory function. No change in BAEP was found when animals were injected with saline or during the baseline period before apamin administration. Results corroborate recent findings from our laboratories of decreased glucose metabolism in brainstem nuclei of the auditory system [3] after injection with the same dose of apamin.",

keywords = "Auditory evoked potential, Bee venom, Brainstem, Neurotoxin, Rat",

author = "Moore, {Bartlett D.} and Massako Kadekaro and Gary, {Howard E.} and Eisenberg, {Howard M.}",

note = "Funding Information: This research was supported by Moody Foundation Grants 84-99B and 86-138. We are grateful to Liz Zindler for her assistance in manuscript preparation.",

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AU - Moore, Bartlett D.

AU - Kadekaro, Massako

AU - Gary, Howard E.

AU - Eisenberg, Howard M.

N1 - Funding Information: This research was supported by Moody Foundation Grants 84-99B and 86-138. We are grateful to Liz Zindler for her assistance in manuscript preparation.

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N2 - Brainstem auditory evoked potentials (BAEPs) were recorded from rats before and after injection with apamin, a polypeptide component of bee venom. Increased absolute and interpeak latencies were found in Peaks III-VII of the BAEP beginning about 30 minutes after apamin injection suggesting impaired auditory function. No change in BAEP was found when animals were injected with saline or during the baseline period before apamin administration. Results corroborate recent findings from our laboratories of decreased glucose metabolism in brainstem nuclei of the auditory system [3] after injection with the same dose of apamin.

AB - Brainstem auditory evoked potentials (BAEPs) were recorded from rats before and after injection with apamin, a polypeptide component of bee venom. Increased absolute and interpeak latencies were found in Peaks III-VII of the BAEP beginning about 30 minutes after apamin injection suggesting impaired auditory function. No change in BAEP was found when animals were injected with saline or during the baseline period before apamin administration. Results corroborate recent findings from our laboratories of decreased glucose metabolism in brainstem nuclei of the auditory system [3] after injection with the same dose of apamin.

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KW - Bee venom

KW - Brainstem

KW - Neurotoxin

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Electrophysiological evidence of the neurotoxic effects of apamin on auditory function in the rat

Abstract

Keywords

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