Elevated prefrontal myo-inositol and choline following breast cancer chemotherapy

Shelli R. Kesler; Christa Watson; Della Koovakkattu; Clement Lee; Ruth O'Hara; Misty L. Mahaffey; Jeffrey S. Wefel

doi:10.1007/s11682-013-9228-1

Elevated prefrontal myo-inositol and choline following breast cancer chemotherapy

Shelli R. Kesler, Christa Watson, Della Koovakkattu, Clement Lee, Ruth O'Hara, Misty L. Mahaffey, Jeffrey S. Wefel

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Breast cancer survivors are at increased risk for cognitive dysfunction, which reduces quality of life. Neuroimaging studies provide critical insights regarding the mechanisms underlying these cognitive deficits as well as potential biologic targets for interventions. We measured several metabolite concentrations using ¹H magnetic resonance spectroscopy as well as cognitive performance in 19 female breast cancer survivors and 17 age-matched female controls. Women with breast cancer were all treated with chemotherapy. Results indicated significantly increased choline (Cho) and myo-inositol (mI) with correspondingly decreased Nacetylaspartate (NAA)/Cho and NAA/mI ratios in the breast cancer group compared to controls. The breast cancer group reported reduced executive function and memory, and subjective memory ability was correlated with mI and Cho levels in both groups. These findings provide preliminary evidence of an altered metabolic profile that increases our understanding of neurobiologic status postbreast cancer and chemotherapy.

Original language	English (US)
Pages (from-to)	501-510
Number of pages	10
Journal	Brain Imaging and Behavior
Volume	7
Issue number	4
DOIs	https://doi.org/10.1007/s11682-013-9228-1
State	Published - Dec 2013

Keywords

Breast Cancer
Chemotherapy
Cognition
MR Spectroscopy
Prefrontal Cortex

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Neurology
Cognitive Neuroscience
Clinical Neurology
Cellular and Molecular Neuroscience
Psychiatry and Mental health
Behavioral Neuroscience

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10.1007/s11682-013-9228-1

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title = "Elevated prefrontal myo-inositol and choline following breast cancer chemotherapy",

abstract = "Breast cancer survivors are at increased risk for cognitive dysfunction, which reduces quality of life. Neuroimaging studies provide critical insights regarding the mechanisms underlying these cognitive deficits as well as potential biologic targets for interventions. We measured several metabolite concentrations using 1H magnetic resonance spectroscopy as well as cognitive performance in 19 female breast cancer survivors and 17 age-matched female controls. Women with breast cancer were all treated with chemotherapy. Results indicated significantly increased choline (Cho) and myo-inositol (mI) with correspondingly decreased Nacetylaspartate (NAA)/Cho and NAA/mI ratios in the breast cancer group compared to controls. The breast cancer group reported reduced executive function and memory, and subjective memory ability was correlated with mI and Cho levels in both groups. These findings provide preliminary evidence of an altered metabolic profile that increases our understanding of neurobiologic status postbreast cancer and chemotherapy.",

keywords = "Breast Cancer, Chemotherapy, Cognition, MR Spectroscopy, Prefrontal Cortex",

author = "Kesler, {Shelli R.} and Christa Watson and Della Koovakkattu and Clement Lee and Ruth O'Hara and Mahaffey, {Misty L.} and Wefel, {Jeffrey S.}",

note = "Funding Information: This study was funded by National Institutes of Health (1 DP2 OD004445-01: SK).",

year = "2013",

month = dec,

doi = "10.1007/s11682-013-9228-1",

language = "English (US)",

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journal = "Brain Imaging and Behavior",

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T1 - Elevated prefrontal myo-inositol and choline following breast cancer chemotherapy

AU - Kesler, Shelli R.

AU - Watson, Christa

AU - Koovakkattu, Della

AU - Lee, Clement

AU - O'Hara, Ruth

AU - Mahaffey, Misty L.

AU - Wefel, Jeffrey S.

N1 - Funding Information: This study was funded by National Institutes of Health (1 DP2 OD004445-01: SK).

PY - 2013/12

Y1 - 2013/12

N2 - Breast cancer survivors are at increased risk for cognitive dysfunction, which reduces quality of life. Neuroimaging studies provide critical insights regarding the mechanisms underlying these cognitive deficits as well as potential biologic targets for interventions. We measured several metabolite concentrations using 1H magnetic resonance spectroscopy as well as cognitive performance in 19 female breast cancer survivors and 17 age-matched female controls. Women with breast cancer were all treated with chemotherapy. Results indicated significantly increased choline (Cho) and myo-inositol (mI) with correspondingly decreased Nacetylaspartate (NAA)/Cho and NAA/mI ratios in the breast cancer group compared to controls. The breast cancer group reported reduced executive function and memory, and subjective memory ability was correlated with mI and Cho levels in both groups. These findings provide preliminary evidence of an altered metabolic profile that increases our understanding of neurobiologic status postbreast cancer and chemotherapy.

AB - Breast cancer survivors are at increased risk for cognitive dysfunction, which reduces quality of life. Neuroimaging studies provide critical insights regarding the mechanisms underlying these cognitive deficits as well as potential biologic targets for interventions. We measured several metabolite concentrations using 1H magnetic resonance spectroscopy as well as cognitive performance in 19 female breast cancer survivors and 17 age-matched female controls. Women with breast cancer were all treated with chemotherapy. Results indicated significantly increased choline (Cho) and myo-inositol (mI) with correspondingly decreased Nacetylaspartate (NAA)/Cho and NAA/mI ratios in the breast cancer group compared to controls. The breast cancer group reported reduced executive function and memory, and subjective memory ability was correlated with mI and Cho levels in both groups. These findings provide preliminary evidence of an altered metabolic profile that increases our understanding of neurobiologic status postbreast cancer and chemotherapy.

KW - Breast Cancer

KW - Chemotherapy

KW - Cognition

KW - MR Spectroscopy

KW - Prefrontal Cortex

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ER -

Elevated prefrontal myo-inositol and choline following breast cancer chemotherapy

Abstract

Keywords

ASJC Scopus subject areas

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