Elevated Serum Thymosin α₁ Levels Associated with Evidence of Immune Dysregulation in Male Homosexuals with a History of Infectious Diseases or Kaposi's Sarcoma

To the Editor: During the past three years, a syndrome of severe opportunistic infection associated with immunodeficiency has been described in male homosexuals.^{1 2 3} Kaposi's sarcoma has also developed in some of these patients. The syndrome has been attributed to the effects of virus infections or to use of recreational drugs.⁴ We have recently had the opportunity to study a group of eight ambulatory, relatively healthy male homosexuals with a good performance status and two homosexuals with limited Kaposi's sarcoma, who were also ambulatory and had a good performance status. All had a history of multiple sexually transmitted diseases, other infections,.