TY - JOUR
T1 - Emerging cellular functions of cytoplasmic PML
AU - Jin, Guoxiang
AU - Wang, Ying Jan
AU - Lin, Hui Kuan
PY - 2013
Y1 - 2013
N2 - The tumor suppressor promyelocytic leukemia protein (PML) is located primarily in the nucleus, where it is the scaffold component of the PML nuclear bodies (PML-NBs). PML-NBs regulate multiple cellular functions, such as apoptosis, senescence, DNA damage response, and resistance to viral infection. Despite its nuclear localization, a small portion of PML has been identified in the cytoplasm. The cytoplasmic PML (cPML) could be originally derived from the retention of exported nuclear PML (nPML). In addition, bona fide cPML isoforms devoid of nuclear localization signal (NLS) have also been identified. Recently, emerging evidence showed that cPML performs its specific cellular functions in tumorigenesis, glycolysis, antiviral responses, laminopothies, and cell cycle regulation. In this review, we will summarize the emerging roles of cPML in cellular functions.
AB - The tumor suppressor promyelocytic leukemia protein (PML) is located primarily in the nucleus, where it is the scaffold component of the PML nuclear bodies (PML-NBs). PML-NBs regulate multiple cellular functions, such as apoptosis, senescence, DNA damage response, and resistance to viral infection. Despite its nuclear localization, a small portion of PML has been identified in the cytoplasm. The cytoplasmic PML (cPML) could be originally derived from the retention of exported nuclear PML (nPML). In addition, bona fide cPML isoforms devoid of nuclear localization signal (NLS) have also been identified. Recently, emerging evidence showed that cPML performs its specific cellular functions in tumorigenesis, glycolysis, antiviral responses, laminopothies, and cell cycle regulation. In this review, we will summarize the emerging roles of cPML in cellular functions.
KW - Antiviral response
KW - Apoptosis
KW - Cytoplasmic PML
KW - TGF-β
KW - Tumorigenesis
UR - http://www.scopus.com/inward/record.url?scp=84891592804&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84891592804&partnerID=8YFLogxK
U2 - 10.3389/fonc.2013.00147
DO - 10.3389/fonc.2013.00147
M3 - Review article
C2 - 23761861
AN - SCOPUS:84891592804
SN - 2234-943X
VL - 3 JUN
JO - Frontiers in Oncology
JF - Frontiers in Oncology
M1 - 00147
ER -