Emerging Influence of the Intestinal Microbiota during Allogeneic Hematopoietic Cell Transplantation: Control the Gut and the Body Will Follow

Melissa D. Docampo; Jeffery J. Auletta; Robert R. Jenq

doi:10.1016/j.bbmt.2015.02.016

Emerging Influence of the Intestinal Microbiota during Allogeneic Hematopoietic Cell Transplantation: Control the Gut and the Body Will Follow

Melissa D. Docampo, Jeffery J. Auletta, Robert R. Jenq

Research output: Contribution to journal › Review article › peer-review

37 Scopus citations

Abstract

The intestinal microbiota has many critical roles in maintaining gastrointestinal epithelial and gastrointestinal systemic immune homeostasis. This review provides insight into how allogeneic hematopoietic cell transplantation (HCT) and its associated complications and supportive care therapies affect the microbiota. Additionally, the review discusses how preservation and restoration of the microbiota might be advantageous in decreasing HCT-related morbidity and mortality.

Original language	English (US)
Pages (from-to)	1360-1366
Number of pages	7
Journal	Biology of Blood and Marrow Transplantation
Volume	21
Issue number	8
DOIs	https://doi.org/10.1016/j.bbmt.2015.02.016
State	Published - Aug 1 2015
Externally published	Yes

Keywords

Antimicrobial peptide
Bacteremia
Bone marrow transplant
Clostridium difficile
Dysbiosis
Enterocyte
Graft-versus-host disease
Gut microbiota
IL-22
Paneth cell
Regenerating islet-derived III alpha
T cell
Tolerance

ASJC Scopus subject areas

Hematology
Transplantation

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10.1016/j.bbmt.2015.02.016

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title = "Emerging Influence of the Intestinal Microbiota during Allogeneic Hematopoietic Cell Transplantation: Control the Gut and the Body Will Follow",

abstract = "The intestinal microbiota has many critical roles in maintaining gastrointestinal epithelial and gastrointestinal systemic immune homeostasis. This review provides insight into how allogeneic hematopoietic cell transplantation (HCT) and its associated complications and supportive care therapies affect the microbiota. Additionally, the review discusses how preservation and restoration of the microbiota might be advantageous in decreasing HCT-related morbidity and mortality.",

keywords = "Antimicrobial peptide, Bacteremia, Bone marrow transplant, Clostridium difficile, Dysbiosis, Enterocyte, Graft-versus-host disease, Gut microbiota, IL-22, Paneth cell, Regenerating islet-derived III alpha, T cell, Tolerance",

author = "Docampo, {Melissa D.} and Auletta, {Jeffery J.} and Jenq, {Robert R.}",

note = "Publisher Copyright: {\textcopyright} 2015 American Society for Blood and Marrow Transplantation.",

year = "2015",

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doi = "10.1016/j.bbmt.2015.02.016",

language = "English (US)",

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T2 - Control the Gut and the Body Will Follow

AU - Docampo, Melissa D.

AU - Auletta, Jeffery J.

AU - Jenq, Robert R.

PY - 2015/8/1

Y1 - 2015/8/1

N2 - The intestinal microbiota has many critical roles in maintaining gastrointestinal epithelial and gastrointestinal systemic immune homeostasis. This review provides insight into how allogeneic hematopoietic cell transplantation (HCT) and its associated complications and supportive care therapies affect the microbiota. Additionally, the review discusses how preservation and restoration of the microbiota might be advantageous in decreasing HCT-related morbidity and mortality.

AB - The intestinal microbiota has many critical roles in maintaining gastrointestinal epithelial and gastrointestinal systemic immune homeostasis. This review provides insight into how allogeneic hematopoietic cell transplantation (HCT) and its associated complications and supportive care therapies affect the microbiota. Additionally, the review discusses how preservation and restoration of the microbiota might be advantageous in decreasing HCT-related morbidity and mortality.

KW - Antimicrobial peptide

KW - Bacteremia

KW - Bone marrow transplant

KW - Clostridium difficile

KW - Dysbiosis

KW - Enterocyte

KW - Graft-versus-host disease

KW - Gut microbiota

KW - IL-22

KW - Paneth cell

KW - Regenerating islet-derived III alpha

KW - T cell

KW - Tolerance

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DO - 10.1016/j.bbmt.2015.02.016

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SN - 1083-8791

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SP - 1360

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JO - Biology of Blood and Marrow Transplantation

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Emerging Influence of the Intestinal Microbiota during Allogeneic Hematopoietic Cell Transplantation: Control the Gut and the Body Will Follow

Abstract

Keywords

ASJC Scopus subject areas

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