Emerging role of KLF4 in human gastrointestinal cancer

Daoyan Wei; Masashi Kanai; Suyun Huang; Keping Xie

doi:10.1093/carcin/bgi243

Emerging role of KLF4 in human gastrointestinal cancer

Daoyan Wei, Masashi Kanai, Suyun Huang, Keping Xie

Research output: Contribution to journal › Review article › peer-review

191 Scopus citations

Abstract

Recent analyses revealed that Krüppel-like factors (KLFs) play important roles in both normal development and carcinogenesis. Of the 16 known KLFs, KLF4 has been shown to be involved in the regulation of proliferation, differentiation and tumorigenesis of gastrointestinal tract epithelium. Clinical, experimental and mechanistic findings indicate that KLF4 is a bona fide tumor suppressor for both gastric and colorectal cancers. In this review, we summarize how this growing area of research has formed and the challenging new frontiers for better understanding of the oncogenic potential of the KLFs.

Original language	English (US)
Pages (from-to)	23-31
Number of pages	9
Journal	Carcinogenesis
Volume	27
Issue number	1
DOIs	https://doi.org/10.1093/carcin/bgi243
State	Published - Jan 2006

ASJC Scopus subject areas

Cancer Research

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title = "Emerging role of KLF4 in human gastrointestinal cancer",

abstract = "Recent analyses revealed that Kr{\"u}ppel-like factors (KLFs) play important roles in both normal development and carcinogenesis. Of the 16 known KLFs, KLF4 has been shown to be involved in the regulation of proliferation, differentiation and tumorigenesis of gastrointestinal tract epithelium. Clinical, experimental and mechanistic findings indicate that KLF4 is a bona fide tumor suppressor for both gastric and colorectal cancers. In this review, we summarize how this growing area of research has formed and the challenging new frontiers for better understanding of the oncogenic potential of the KLFs.",

author = "Daoyan Wei and Masashi Kanai and Suyun Huang and Keping Xie",

note = "Funding Information: The authors thank Judy King for the expert help in the preparation of this manuscript and Don Norwood for the editorial comments. This work was supported by the Research Scholar Grant CSM-106640 from the American Cancer Society, the SPORE grant in Pancreatic Cancer (1P20-CA101936-01-PP4), and Grant 1R01-CA093829 from the National Cancer Institute, National Institutes of Health (to K.X. and S.H.).",

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doi = "10.1093/carcin/bgi243",

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AU - Wei, Daoyan

AU - Kanai, Masashi

AU - Huang, Suyun

AU - Xie, Keping

N1 - Funding Information: The authors thank Judy King for the expert help in the preparation of this manuscript and Don Norwood for the editorial comments. This work was supported by the Research Scholar Grant CSM-106640 from the American Cancer Society, the SPORE grant in Pancreatic Cancer (1P20-CA101936-01-PP4), and Grant 1R01-CA093829 from the National Cancer Institute, National Institutes of Health (to K.X. and S.H.).

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N2 - Recent analyses revealed that Krüppel-like factors (KLFs) play important roles in both normal development and carcinogenesis. Of the 16 known KLFs, KLF4 has been shown to be involved in the regulation of proliferation, differentiation and tumorigenesis of gastrointestinal tract epithelium. Clinical, experimental and mechanistic findings indicate that KLF4 is a bona fide tumor suppressor for both gastric and colorectal cancers. In this review, we summarize how this growing area of research has formed and the challenging new frontiers for better understanding of the oncogenic potential of the KLFs.

AB - Recent analyses revealed that Krüppel-like factors (KLFs) play important roles in both normal development and carcinogenesis. Of the 16 known KLFs, KLF4 has been shown to be involved in the regulation of proliferation, differentiation and tumorigenesis of gastrointestinal tract epithelium. Clinical, experimental and mechanistic findings indicate that KLF4 is a bona fide tumor suppressor for both gastric and colorectal cancers. In this review, we summarize how this growing area of research has formed and the challenging new frontiers for better understanding of the oncogenic potential of the KLFs.

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Emerging role of KLF4 in human gastrointestinal cancer

Abstract

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