Emerging treatment paradigms in radiation oncology

Quynh Thu Le; Hiroki Shirato; Amato J. Giaccia; Albert C. Koong

doi:10.1158/1078-0432.CCR-14-1191

Emerging treatment paradigms in radiation oncology

Quynh Thu Le, Hiroki Shirato, Amato J. Giaccia, Albert C. Koong

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31 Scopus citations

Abstract

Rapid advancements in radiotherapy and molecularly targeted therapies have resulted in the development of potential paradigm-shifting use of radiotherapy in the treatment of cancer. In this review, we discuss some of the most promising therapeutic approaches in the field of radiation oncology. These strategies include the use of highly targeted stereotactic radiotherapy and particle therapy as well as combining radiotherapy with agents that modulate the DNA damage response, augment the immune response, or protect normal tissues.

Original language	English (US)
Pages (from-to)	3393-3401
Number of pages	9
Journal	Clinical Cancer Research
Volume	21
Issue number	15
DOIs	https://doi.org/10.1158/1078-0432.CCR-14-1191
State	Published - Aug 1 2015

ASJC Scopus subject areas

Oncology
Cancer Research

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abstract = "Rapid advancements in radiotherapy and molecularly targeted therapies have resulted in the development of potential paradigm-shifting use of radiotherapy in the treatment of cancer. In this review, we discuss some of the most promising therapeutic approaches in the field of radiation oncology. These strategies include the use of highly targeted stereotactic radiotherapy and particle therapy as well as combining radiotherapy with agents that modulate the DNA damage response, augment the immune response, or protect normal tissues.",

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AU - Shirato, Hiroki

AU - Giaccia, Amato J.

AU - Koong, Albert C.

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AB - Rapid advancements in radiotherapy and molecularly targeted therapies have resulted in the development of potential paradigm-shifting use of radiotherapy in the treatment of cancer. In this review, we discuss some of the most promising therapeutic approaches in the field of radiation oncology. These strategies include the use of highly targeted stereotactic radiotherapy and particle therapy as well as combining radiotherapy with agents that modulate the DNA damage response, augment the immune response, or protect normal tissues.

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Emerging treatment paradigms in radiation oncology

Abstract

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