Abstract
Although the role of the breast cancer gene 2 (BRCA2) tumor suppressor gene is well established in inherited breast and ovarian carcinomas, its involvement in sporadic disease is still uncertain. The recent identification of a novel BRCA2 binding protein, EMSY, as a putative oncogene implicates the BRCA2 pathway in sporadic tumors. Furthermore, EMSY's binding to members of the 'Royal Family' of chromatin remodeling proteins may lead to a better understanding of the physiological function of BRCA2 and its role in chromatin remodeling.
Original language | English (US) |
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Pages (from-to) | 201-203 |
Number of pages | 3 |
Journal | Breast Cancer Research |
Volume | 6 |
Issue number | 5 |
DOIs |
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State | Published - Sep 2004 |
Externally published | Yes |
Keywords
- BRCA2
- Breast cancer
- EMSY
- Familiar
- Sporadic
ASJC Scopus subject areas
- Cancer Research
- Oncology