TY - JOUR
T1 - EMT
T2 - When epithelial cells decide to become mesenchymal-like cells
AU - Kalluri, Raghu
PY - 2009/6/1
Y1 - 2009/6/1
N2 - Epithelial-mesenchymal transition (EMT) is critical for appropriate embryonic development, and this process is re-engaged in adults during wound healing, tissue regeneration, organ fibrosis, and cancer progression. Inflammation is a crucial conspirator in the emergence of EMT in adults but is absent during embryonic development. As highlighted in this Review series, EMT is now a recognized mechanism for dispersing cells in embryos, forming fibroblasts/mesenchymal cells in injured tissues, and initiating metastasis of epithelial cancer cells. Also discussed are proposals to classify EMT into three subtypes, each of which has different functional consequences.
AB - Epithelial-mesenchymal transition (EMT) is critical for appropriate embryonic development, and this process is re-engaged in adults during wound healing, tissue regeneration, organ fibrosis, and cancer progression. Inflammation is a crucial conspirator in the emergence of EMT in adults but is absent during embryonic development. As highlighted in this Review series, EMT is now a recognized mechanism for dispersing cells in embryos, forming fibroblasts/mesenchymal cells in injured tissues, and initiating metastasis of epithelial cancer cells. Also discussed are proposals to classify EMT into three subtypes, each of which has different functional consequences.
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U2 - 10.1172/JCI39675
DO - 10.1172/JCI39675
M3 - Review article
C2 - 19487817
AN - SCOPUS:67651005404
SN - 0021-9738
VL - 119
SP - 1417
EP - 1419
JO - Journal of Clinical Investigation
JF - Journal of Clinical Investigation
IS - 6
ER -