Endocrine

Jeena Varghese; Conor Best

doi:10.1007/978-3-031-00241-0_4

Endocrine

Jeena Varghese, Conor Best

Endocrine Neoplasia & HD

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Immune checkpoint inhibitors have been approved for treatment of various malignancies. Endocrine dysfunction is one of the most common adverse effects and includes hypophysitis, thyroid dysfunction, insulin-deficient diabetes, and adrenal insufficiency. Diagnosis can be challenging as onset is variable and patients can have damage to more than one organ. However, if diagnosed appropriately and treated in a timely manner, the patients can continue immunotherapy. In this chapter, we present an overview of clinical presentation, diagnosis, management, and long-term follow-up of the more common endocrine adverse effects.

Original language	English (US)
Title of host publication	Managing Immunotherapy Related Organ Toxicities
Subtitle of host publication	A Practical Guide
Publisher	Springer International Publishing
Pages	59-79
Number of pages	21
ISBN (Electronic)	9783031002410
ISBN (Print)	9783031002403
DOIs	https://doi.org/10.1007/978-3-031-00241-0_4
State	Published - Jan 1 2022

Keywords

Adrenal insufficiency
Checkpoint inhibitor-induced diabetes
Hypophysitis
Hypothyroidism
Thyrotoxicosis

ASJC Scopus subject areas

General Medicine
General Immunology and Microbiology

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10.1007/978-3-031-00241-0_4

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AB - Immune checkpoint inhibitors have been approved for treatment of various malignancies. Endocrine dysfunction is one of the most common adverse effects and includes hypophysitis, thyroid dysfunction, insulin-deficient diabetes, and adrenal insufficiency. Diagnosis can be challenging as onset is variable and patients can have damage to more than one organ. However, if diagnosed appropriately and treated in a timely manner, the patients can continue immunotherapy. In this chapter, we present an overview of clinical presentation, diagnosis, management, and long-term follow-up of the more common endocrine adverse effects.

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KW - Hypothyroidism

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Endocrine

Abstract

Keywords

ASJC Scopus subject areas

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