Endogenous inhibitors of angiogenesis

Malin Sund; Raghu Kalluri

doi:10.1007/978-3-540-33177-3_12

Endogenous inhibitors of angiogenesis

Malin Sund, Raghu Kalluri

Research output: Chapter in Book/Report/Conference proceeding › Chapter

7 Scopus citations

Abstract

During angiogenesis new blood vessels are formed from pre-existing blood vessels. Tumor angiogenesis enables a small colony of malignantly transformed cells to grow and develop into an invasive cancer. This process is believed to be regulated by a change in the balance between endogenous pro-angiogenic and anti-angiogenic factors, and thus tumor growth requires a shift towards pro-angiogenesis. There are now extensive genetic data available from animal models that illustrate that the ceiling growth rate of a cancer is strongly influenced by the angiogenic potential of the host. This concept will be discussed in this chapter. We will also introduce the reader to the known matrix-derived and other endogenous inhibitors on angiogenesis, and their mechanism of action.

Original language	English (US)
Title of host publication	Tumor Angiogenesis
Subtitle of host publication	Basic Mechanisms and Cancer Therapy
Publisher	Springer Berlin Heidelberg
Pages	215-231
Number of pages	17
ISBN (Print)	9783540331766
DOIs	https://doi.org/10.1007/978-3-540-33177-3_12
State	Published - 2008
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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10.1007/978-3-540-33177-3_12

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title = "Endogenous inhibitors of angiogenesis",

abstract = "During angiogenesis new blood vessels are formed from pre-existing blood vessels. Tumor angiogenesis enables a small colony of malignantly transformed cells to grow and develop into an invasive cancer. This process is believed to be regulated by a change in the balance between endogenous pro-angiogenic and anti-angiogenic factors, and thus tumor growth requires a shift towards pro-angiogenesis. There are now extensive genetic data available from animal models that illustrate that the ceiling growth rate of a cancer is strongly influenced by the angiogenic potential of the host. This concept will be discussed in this chapter. We will also introduce the reader to the known matrix-derived and other endogenous inhibitors on angiogenesis, and their mechanism of action.",

author = "Malin Sund and Raghu Kalluri",

note = "Funding Information: Supported in part by MIUR (PRIN 2007), Rome, and Fondazione Cassa di Risparmio di Puglia, Bari, Italy.",

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T1 - Endogenous inhibitors of angiogenesis

AU - Sund, Malin

AU - Kalluri, Raghu

N1 - Funding Information: Supported in part by MIUR (PRIN 2007), Rome, and Fondazione Cassa di Risparmio di Puglia, Bari, Italy.

PY - 2008

Y1 - 2008

N2 - During angiogenesis new blood vessels are formed from pre-existing blood vessels. Tumor angiogenesis enables a small colony of malignantly transformed cells to grow and develop into an invasive cancer. This process is believed to be regulated by a change in the balance between endogenous pro-angiogenic and anti-angiogenic factors, and thus tumor growth requires a shift towards pro-angiogenesis. There are now extensive genetic data available from animal models that illustrate that the ceiling growth rate of a cancer is strongly influenced by the angiogenic potential of the host. This concept will be discussed in this chapter. We will also introduce the reader to the known matrix-derived and other endogenous inhibitors on angiogenesis, and their mechanism of action.

AB - During angiogenesis new blood vessels are formed from pre-existing blood vessels. Tumor angiogenesis enables a small colony of malignantly transformed cells to grow and develop into an invasive cancer. This process is believed to be regulated by a change in the balance between endogenous pro-angiogenic and anti-angiogenic factors, and thus tumor growth requires a shift towards pro-angiogenesis. There are now extensive genetic data available from animal models that illustrate that the ceiling growth rate of a cancer is strongly influenced by the angiogenic potential of the host. This concept will be discussed in this chapter. We will also introduce the reader to the known matrix-derived and other endogenous inhibitors on angiogenesis, and their mechanism of action.

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SN - 9783540331766

SP - 215

EP - 231

BT - Tumor Angiogenesis

PB - Springer Berlin Heidelberg

ER -

Endogenous inhibitors of angiogenesis

Abstract

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