Abstract
Endostatin, a 20 kDa C-terminal fragment of collagen XVIII, was first identified as a potent angiogenic inhibitor. The anti-angiogenic function of endostatin has been well documented during the past decade. Recently, several studies demonstrated that endostatin also inhibits tumor lymphangiogenesis and lymphatic metastasis. However, the exact mechanism that endostatin executes its anti-angiogenic and anti-lymphangiogenic functions remains elusive. In the current mini-review, we briefly summarize recent novel findings, including the functions of endostatin targeting not only angiogenesis but also lymphangiogenesis, and the underlying mechanism by which endostatin internalization regulates its biological functions.
Original language | English (US) |
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Pages (from-to) | 336-340 |
Number of pages | 5 |
Journal | Frontiers of Medicine in China |
Volume | 5 |
Issue number | 4 |
DOIs | |
State | Published - Dec 2011 |
Externally published | Yes |
Keywords
- angiogenesis
- endostatin
- internalization
- lymphangiogenesis
- nystatin
- tumor
ASJC Scopus subject areas
- General Medicine