Abstract
Bacterial endotoxin was administered with iodoacetamide modified P1798 lymphoma cells to immunize syngenic BALB/cJ mice against this lymphoma to which they are naturally unresponsive. 3 Or 4 vaccinations with endotoxin (6.6 μg/injection) alone or the modified cells alone did not produce host resistance. A significant number (30%) of mice receiving both endotoxin and modified cells rejected a subsequent implant of viable tumor cells. Even those mice having progressive tumor growth exhibited prolonged survival. High doses of endotoxin given with the modified P1798 cells caused 70-75% of the mice to reject the tumor implants. When resistance developed, antibodies reacting with tumor cell membrane were demonstrable. These results indicate that B-lymphocyte stimulators can produce an effective immune response against lymphoma cells.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 773-775 |
| Number of pages | 3 |
| Journal | Journal of the National Cancer Institute |
| Volume | 54 |
| Issue number | 3 |
| State | Published - 1975 |
ASJC Scopus subject areas
- Oncology
- Cancer Research