TY - JOUR
T1 - Enemy of the (immunosuppressed) state
T2 - An update on the pathogenesis of Aspergillus fumigatus infection
AU - Ben-Ami, Ronen
AU - Lewis, Russell E.
AU - Kontoyiannis, Dimitrios P.
N1 - Copyright:
Copyright 2010 Elsevier B.V., All rights reserved.
PY - 2010/8
Y1 - 2010/8
N2 - Aspergillus fumigatus is an opportunistic filamentous fungus that is currently the most frequent cause of invasive fungal disease in immunosuppressed individuals. Recent advances in our understanding of the pathogenesis of invasive aspergillosis have highlighted the multifactorial nature of A. fumigatus virulence and the complex interplay between host and microbial factors. In this review, we outline current concepts of immune recognition and evasion, angioinvasion and angiogenesis, secondary metabolism and the fungal stress response, and their respective roles in this often lethal infection.
AB - Aspergillus fumigatus is an opportunistic filamentous fungus that is currently the most frequent cause of invasive fungal disease in immunosuppressed individuals. Recent advances in our understanding of the pathogenesis of invasive aspergillosis have highlighted the multifactorial nature of A. fumigatus virulence and the complex interplay between host and microbial factors. In this review, we outline current concepts of immune recognition and evasion, angioinvasion and angiogenesis, secondary metabolism and the fungal stress response, and their respective roles in this often lethal infection.
KW - Aspergillus fumigatus
KW - immunosuppressed state
KW - pathogenesis
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U2 - 10.1111/j.1365-2141.2010.08283.x
DO - 10.1111/j.1365-2141.2010.08283.x
M3 - Review article
C2 - 20618330
AN - SCOPUS:77955148951
SN - 0007-1048
VL - 150
SP - 406
EP - 417
JO - British Journal of Haematology
JF - British Journal of Haematology
IS - 4
ER -