Enhancement of aryl hydrocarbon hydroxylase activity in cultured rodent cells by x-irradiation

Natarajan Venkatesan; Lawrence J. Alfred; Gloria Torralba; William F. Benedict

doi:10.1016/0024-3205(79)90363-1

Enhancement of aryl hydrocarbon hydroxylase activity in cultured rodent cells by x-irradiation

Natarajan Venkatesan, Lawrence J. Alfred, Gloria Torralba, William F. Benedict

Genitourinary Medical Oncology

Research output: Contribution to journal › Article › peer-review

Abstract

X-irradiation (500 rads) was found to enhance the aryl hydrocarbon hydroxylase (AHH) activity of three cell lines. Radiation followed by induction with benz (a) anthracene (5-15 μg/ml) produced a synergistic effect on AHH. These effects were highly significant and were observed most dramatically with a hamster tumor cell line, A(T_l)Cl-3,a nd to a lesser extent in secondary hamsters embryo cells and mouse C3H/10T 1 2 CL8 cells.

Original language	English (US)
Pages (from-to)	797-802
Number of pages	6
Journal	Life Sciences
Volume	24
Issue number	9
DOIs	https://doi.org/10.1016/0024-3205(79)90363-1
State	Published - Feb 26 1979

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1016/0024-3205(79)90363-1

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title = "Enhancement of aryl hydrocarbon hydroxylase activity in cultured rodent cells by x-irradiation",

abstract = "X-irradiation (500 rads) was found to enhance the aryl hydrocarbon hydroxylase (AHH) activity of three cell lines. Radiation followed by induction with benz (a) anthracene (5-15 μg/ml) produced a synergistic effect on AHH. These effects were highly significant and were observed most dramatically with a hamster tumor cell line, A(Tl)Cl-3,a nd to a lesser extent in secondary hamsters embryo cells and mouse C3H/10T 1 2 CL8 cells.",

author = "Natarajan Venkatesan and Alfred, {Lawrence J.} and Gloria Torralba and Benedict, {William F.}",

note = "Funding Information: ~17R work was supported by NIIi Research Grants CA-14226, CA--19659 and RR-08140 (MHSP) aryl Camcil Fas 7Ubacco Research Grant 1027 . W.F .B . is a recipi~t of a Research Career Developnent Award fron NIH. We are grateful to Dr . Robert Hittle of the Radiology Department at Childrens Hospital far his assistance in X-irradiating cells and to Ms . Mary Haken far her techaioal assistance.",

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doi = "10.1016/0024-3205(79)90363-1",

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T1 - Enhancement of aryl hydrocarbon hydroxylase activity in cultured rodent cells by x-irradiation

AU - Venkatesan, Natarajan

AU - Alfred, Lawrence J.

AU - Torralba, Gloria

AU - Benedict, William F.

N1 - Funding Information: ~17R work was supported by NIIi Research Grants CA-14226, CA--19659 and RR-08140 (MHSP) aryl Camcil Fas 7Ubacco Research Grant 1027 . W.F .B . is a recipi~t of a Research Career Developnent Award fron NIH. We are grateful to Dr . Robert Hittle of the Radiology Department at Childrens Hospital far his assistance in X-irradiating cells and to Ms . Mary Haken far her techaioal assistance.

PY - 1979/2/26

Y1 - 1979/2/26

N2 - X-irradiation (500 rads) was found to enhance the aryl hydrocarbon hydroxylase (AHH) activity of three cell lines. Radiation followed by induction with benz (a) anthracene (5-15 μg/ml) produced a synergistic effect on AHH. These effects were highly significant and were observed most dramatically with a hamster tumor cell line, A(Tl)Cl-3,a nd to a lesser extent in secondary hamsters embryo cells and mouse C3H/10T 1 2 CL8 cells.

AB - X-irradiation (500 rads) was found to enhance the aryl hydrocarbon hydroxylase (AHH) activity of three cell lines. Radiation followed by induction with benz (a) anthracene (5-15 μg/ml) produced a synergistic effect on AHH. These effects were highly significant and were observed most dramatically with a hamster tumor cell line, A(Tl)Cl-3,a nd to a lesser extent in secondary hamsters embryo cells and mouse C3H/10T 1 2 CL8 cells.

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Enhancement of aryl hydrocarbon hydroxylase activity in cultured rodent cells by x-irradiation

Abstract

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