TY - JOUR
T1 - Enhancement of fludioxonil fungicidal activity by disrupting cellular glutathione homeostasis with 2,5-dihydroxybenzoic acid
AU - Kim, Jong H.
AU - Campbell, Bruce C.
AU - Mahoney, Noreen
AU - Chan, Kathleen L.
AU - Molyneux, Russell J.
AU - May, Gregory S.
PY - 2007/5
Y1 - 2007/5
N2 - The activity of fludioxonil, a phenylpyrrole fungicide, is elevated by coapplication of the aspirin/salicylic acid metabolite, 2,5-dihydroxybenzoic acid (2,5-DHBA). Fludioxonil activity is potentiated through a mitogen-activated protein kinase (MAPK) pathway that regulates osmotic/oxidative stress-responses. 2,5-DHBA disrupts cellular GSH (reduced glutathione)/GSSG (oxidized glutathione) homeostasis, further stressing the oxidative stress-response system. This stress enhances fludioxonil activity. 2,5-DHBA treatment also prevents tolerance of MAPK mutants resistant to fludioxonil.
AB - The activity of fludioxonil, a phenylpyrrole fungicide, is elevated by coapplication of the aspirin/salicylic acid metabolite, 2,5-dihydroxybenzoic acid (2,5-DHBA). Fludioxonil activity is potentiated through a mitogen-activated protein kinase (MAPK) pathway that regulates osmotic/oxidative stress-responses. 2,5-DHBA disrupts cellular GSH (reduced glutathione)/GSSG (oxidized glutathione) homeostasis, further stressing the oxidative stress-response system. This stress enhances fludioxonil activity. 2,5-DHBA treatment also prevents tolerance of MAPK mutants resistant to fludioxonil.
KW - 2,5-dihydroxybenzoic acid
KW - Antioxidative stress system
KW - Aspergillus
KW - Fludioxonil
KW - Saccharomyces cerevisiae
UR - http://www.scopus.com/inward/record.url?scp=34247131370&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34247131370&partnerID=8YFLogxK
U2 - 10.1111/j.1574-6968.2007.00682.x
DO - 10.1111/j.1574-6968.2007.00682.x
M3 - Article
C2 - 17355596
AN - SCOPUS:34247131370
SN - 0378-1097
VL - 270
SP - 284
EP - 290
JO - FEMS Microbiology Letters
JF - FEMS Microbiology Letters
IS - 2
ER -