Enhancement of radiotherapy by oleandrin is a caspase-3 dependent process

Sachiko Nasu; Luka Milas; Shinichiro Kawabe; Uma Raju; Robert A. Newman

doi:10.1016/S0304-3835(02)00263-X

Enhancement of radiotherapy by oleandrin is a caspase-3 dependent process

Sachiko Nasu, Luka Milas, Shinichiro Kawabe, Uma Raju, Robert A. Newman

Experimental Radiation Oncology

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

Cardiac glycosides such as digitoxin and ouabain have previously been shown to be selectively cytotoxic to tumor as opposed to normal cells. Moreover, this class of agents has also been shown to act as potent radiosensitizers. In the present study we explored the relative radiosensitization potential of oleandrin, a cardiac glycoside contained within the plant extract known as Anvirze

Original language	English (US)
Pages (from-to)	145-151
Number of pages	7
Journal	Cancer Letters
Volume	185
Issue number	2
DOIs	https://doi.org/10.1016/S0304-3835(02)00263-X
State	Published - Nov 28 2002

Keywords

Cardiac glycosides
Caspase-3
Oleandrin
Radiotherapy

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/S0304-3835(02)00263-X

Cite this

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abstract = "Cardiac glycosides such as digitoxin and ouabain have previously been shown to be selectively cytotoxic to tumor as opposed to normal cells. Moreover, this class of agents has also been shown to act as potent radiosensitizers. In the present study we explored the relative radiosensitization potential of oleandrin, a cardiac glycoside contained within the plant extract known as Anvirze",

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AU - Nasu, Sachiko

AU - Milas, Luka

AU - Kawabe, Shinichiro

AU - Raju, Uma

AU - Newman, Robert A.

PY - 2002/11/28

Y1 - 2002/11/28

N2 - Cardiac glycosides such as digitoxin and ouabain have previously been shown to be selectively cytotoxic to tumor as opposed to normal cells. Moreover, this class of agents has also been shown to act as potent radiosensitizers. In the present study we explored the relative radiosensitization potential of oleandrin, a cardiac glycoside contained within the plant extract known as Anvirze

AB - Cardiac glycosides such as digitoxin and ouabain have previously been shown to be selectively cytotoxic to tumor as opposed to normal cells. Moreover, this class of agents has also been shown to act as potent radiosensitizers. In the present study we explored the relative radiosensitization potential of oleandrin, a cardiac glycoside contained within the plant extract known as Anvirze

KW - Cardiac glycosides

KW - Caspase-3

KW - Oleandrin

KW - Radiotherapy

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JO - Cancer Letters

JF - Cancer Letters

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ER -

Enhancement of radiotherapy by oleandrin is a caspase-3 dependent process

Abstract

Keywords

ASJC Scopus subject areas

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