TY - JOUR
T1 - Enhancing Cancer Diagnosis with Real-Time Feedback
T2 - Tumor Metabolism through Hyperpolarized 1-13C Pyruvate MRSI
AU - Sharma, Gaurav
AU - Enriquez, José S.
AU - Armijo, Ryan
AU - Wang, Muxin
AU - Bhattacharya, Pratip
AU - Pudakalakatti, Shivanand
N1 - Publisher Copyright:
© 2023 by the authors.
PY - 2023/5
Y1 - 2023/5
N2 - This review article discusses the potential of hyperpolarized (HP) 13C magnetic resonance spectroscopic imaging (MRSI) as a noninvasive technique for identifying altered metabolism in various cancer types. Hyperpolarization significantly improves the signal-to-noise ratio for the identification of 13C-labeled metabolites, enabling dynamic and real-time imaging of the conversion of [1-13C] pyruvate to [1-13C] lactate and/or [1-13C] alanine. The technique has shown promise in identifying upregulated glycolysis in most cancers, as compared to normal cells, and detecting successful treatment responses at an earlier stage than multiparametric MRI in breast and prostate cancer patients. The review provides a concise overview of the applications of HP [1-13C] pyruvate MRSI in various cancer systems, highlighting its potential for use in preclinical and clinical investigations, precision medicine, and long-term studies of therapeutic response. The article also discusses emerging frontiers in the field, such as combining multiple metabolic imaging techniques with HP MRSI for a more comprehensive view of cancer metabolism, and leveraging artificial intelligence to develop real-time, actionable biomarkers for early detection, assessing aggressiveness, and interrogating the early efficacy of therapies.
AB - This review article discusses the potential of hyperpolarized (HP) 13C magnetic resonance spectroscopic imaging (MRSI) as a noninvasive technique for identifying altered metabolism in various cancer types. Hyperpolarization significantly improves the signal-to-noise ratio for the identification of 13C-labeled metabolites, enabling dynamic and real-time imaging of the conversion of [1-13C] pyruvate to [1-13C] lactate and/or [1-13C] alanine. The technique has shown promise in identifying upregulated glycolysis in most cancers, as compared to normal cells, and detecting successful treatment responses at an earlier stage than multiparametric MRI in breast and prostate cancer patients. The review provides a concise overview of the applications of HP [1-13C] pyruvate MRSI in various cancer systems, highlighting its potential for use in preclinical and clinical investigations, precision medicine, and long-term studies of therapeutic response. The article also discusses emerging frontiers in the field, such as combining multiple metabolic imaging techniques with HP MRSI for a more comprehensive view of cancer metabolism, and leveraging artificial intelligence to develop real-time, actionable biomarkers for early detection, assessing aggressiveness, and interrogating the early efficacy of therapies.
KW - artificial intelligence
KW - biomarkers
KW - cancer metabolism
KW - hyperpolarized (HP) C magnetic resonance spectroscopic imaging (MRSI)
KW - precision medicine
KW - pyruvate-to-lactate metabolic reprogramming
KW - therapeutic intervention
UR - http://www.scopus.com/inward/record.url?scp=85160361578&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85160361578&partnerID=8YFLogxK
U2 - 10.3390/metabo13050606
DO - 10.3390/metabo13050606
M3 - Review article
C2 - 37233647
AN - SCOPUS:85160361578
SN - 2218-1989
VL - 13
JO - Metabolites
JF - Metabolites
IS - 5
M1 - 606
ER -