TY - JOUR
T1 - Enzyme-linked PNA lectin-binding assay of serum T-antigen in patients with SCC of the uterine cervix
AU - Reddi, Alagarsamy Lakku
AU - Sankaranarayanan, Kannan
AU - Arulraj, Harold Stephen
AU - Devaraj, Niranjali
AU - Devaraj, Halagowder
N1 - Funding Information:
The authors would like to thank the Director and Assistant Professors of Barnard Institute of Radiation & Oncology, General Hospital, Madras Medical College, Chennai, for providing blood samples from cancer patients. One of the authors, Dr A.L. Reddi, would like to thank the University Grants Commission (UGC), India, for financial assistance.
PY - 2000/2/28
Y1 - 2000/2/28
N2 - The expression of Thomsen-Friendenreich antigen (T-Ag) is associated with enhanced metastatic potential, poor prognosis and decreased survival rate in a variety of malignancies, and their detection and quantification can be used in serologic diagnosis. T-antigen expressions were measured by the enzyme-linked lectin assay (ELLA) with peanut agglutinin (PNA) in the sera of patients with squamous cell carcinoma (SCC) of the uterine cervix from 286 patients. This study has a sensitivity of 80%, specificity of 82% and a positive predictive value of 93%. Quantification of the T-antigen may provide useful biochemical indices for clinical assessment of the tumor spread and invasiveness of disease in SCC of the uterine cervix. Moreover, the ELLA assay is cheap, easy to perform and reproducible in the prognosis and diagnosis of SCC of the uterine cervix. (C) 2000 Elsevier Science Ireland Ltd.
AB - The expression of Thomsen-Friendenreich antigen (T-Ag) is associated with enhanced metastatic potential, poor prognosis and decreased survival rate in a variety of malignancies, and their detection and quantification can be used in serologic diagnosis. T-antigen expressions were measured by the enzyme-linked lectin assay (ELLA) with peanut agglutinin (PNA) in the sera of patients with squamous cell carcinoma (SCC) of the uterine cervix from 286 patients. This study has a sensitivity of 80%, specificity of 82% and a positive predictive value of 93%. Quantification of the T-antigen may provide useful biochemical indices for clinical assessment of the tumor spread and invasiveness of disease in SCC of the uterine cervix. Moreover, the ELLA assay is cheap, easy to perform and reproducible in the prognosis and diagnosis of SCC of the uterine cervix. (C) 2000 Elsevier Science Ireland Ltd.
KW - Enzyme-linked lectin assay (ELLA)
KW - Mucin
KW - Squamous cell carcinoma (SCC)
KW - T-antigen
KW - Uterine cervix
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U2 - 10.1016/S0304-3835(99)00363-8
DO - 10.1016/S0304-3835(99)00363-8
M3 - Article
C2 - 10737726
AN - SCOPUS:0033963287
SN - 0304-3835
VL - 149
SP - 207
EP - 211
JO - Cancer Letters
JF - Cancer Letters
IS - 1-2
ER -