EP3 prostaglandin receptors in the median preoptic nucleus are critical for fever responses

Michael Lazarus; Kyoko Yoshida; Roberto Coppari; Caroline E. Bass; Takatoshi Mochizuki; Bradford B. Lowell; Clifford B. Saper

doi:10.1038/nn1949

EP3 prostaglandin receptors in the median preoptic nucleus are critical for fever responses

Michael Lazarus, Kyoko Yoshida, Roberto Coppari, Caroline E. Bass, Takatoshi Mochizuki, Bradford B. Lowell, Clifford B. Saper

Research output: Contribution to journal › Article › peer-review

269 Scopus citations

Abstract

Fever is a result of the action of prostaglandin E2 (PGE2) on the brain and appears to require EP3 prostaglandin receptors (EP3Rs), but the specific neurons on which PGE2 acts to produce fever have not been definitively established. Here we report that selective genetic deletion of the EP3Rs in the median preoptic nucleus of mice resulted in abrogation of the fever response. These observations demonstrate that the EP3R-bearing neurons in the median preoptic nucleus are required for fever responses.

Original language	English (US)
Pages (from-to)	1131-1133
Number of pages	3
Journal	Nature Neuroscience
Volume	10
Issue number	9
DOIs	https://doi.org/10.1038/nn1949
State	Published - Sep 2007
Externally published	Yes

ASJC Scopus subject areas

General Neuroscience

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title = "EP3 prostaglandin receptors in the median preoptic nucleus are critical for fever responses",

abstract = "Fever is a result of the action of prostaglandin E2 (PGE2) on the brain and appears to require EP3 prostaglandin receptors (EP3Rs), but the specific neurons on which PGE2 acts to produce fever have not been definitively established. Here we report that selective genetic deletion of the EP3Rs in the median preoptic nucleus of mice resulted in abrogation of the fever response. These observations demonstrate that the EP3R-bearing neurons in the median preoptic nucleus are required for fever responses.",

author = "Michael Lazarus and Kyoko Yoshida and Roberto Coppari and Bass, {Caroline E.} and Takatoshi Mochizuki and Lowell, {Bradford B.} and Saper, {Clifford B.}",

note = "Funding Information: We would like to thank Q. Ha, M. Ha and J. Yu for superb technical assistance and J. Lu, N.L. Chamberlin, J.K. Elmquist and O. Hayaishi for critical reading of the manuscript and valuable comments. This research was supported by US Public Health Service grants NS33987 and HL60292.",

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AU - Lazarus, Michael

AU - Yoshida, Kyoko

AU - Coppari, Roberto

AU - Bass, Caroline E.

AU - Mochizuki, Takatoshi

AU - Lowell, Bradford B.

AU - Saper, Clifford B.

N1 - Funding Information: We would like to thank Q. Ha, M. Ha and J. Yu for superb technical assistance and J. Lu, N.L. Chamberlin, J.K. Elmquist and O. Hayaishi for critical reading of the manuscript and valuable comments. This research was supported by US Public Health Service grants NS33987 and HL60292.

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AB - Fever is a result of the action of prostaglandin E2 (PGE2) on the brain and appears to require EP3 prostaglandin receptors (EP3Rs), but the specific neurons on which PGE2 acts to produce fever have not been definitively established. Here we report that selective genetic deletion of the EP3Rs in the median preoptic nucleus of mice resulted in abrogation of the fever response. These observations demonstrate that the EP3R-bearing neurons in the median preoptic nucleus are required for fever responses.

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EP3 prostaglandin receptors in the median preoptic nucleus are critical for fever responses

Abstract

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