TY - JOUR
T1 - Epidemiology of Cutaneous Leishmaniasis in Colombia
T2 - A Longitudinal Study of the Natural History, Prevalence, and Incidence of Infection and Clinical Manifestations
AU - Weigle, Kristen A.
AU - Santrich, Cecilia
AU - Martinez, Fernando
AU - Valderrama, Liliana
AU - Saravia, Nancy G.
AU - Weigle, Kristen A.
AU - Santrich, Cecilia
AU - Martinez, Fernando
AU - Valderrama, Liliana
AU - Saravia, Nancy G.
N1 - Funding Information:
Received 17 July 1992; revised 22 October 1992. Presented in part: Latin American Congress of Tropical Medicine. Mexico City. May 1990 (abstract 118) and the International Development Research Centre workshop on the control of leishmaniasis. Merida, Mexico, November 1991. Written informed consent was obtained from the participants or, in the case of minors, their parents or guardians. Human experimental guidelines of the US Department of Health and Human Services and those of the Ethical Review Board of the Fundacion para la Educacion Superior were followed. Financial support: International Development Research Centre of Canada (project 3-P-85-0279); National Institutes of Health (AI-16315); United Nations Development Programme/World Health Organization Special Programme for Research and Training in Tropical Diseases (grant 840336); Mellon Foundation (to K.A.W.). Reprints or correspondence: Dr. Kristen A. Weigle. Department ofEpidemiology, CB 7400. University of North Carolina. Chapel Hill, NC 27599-7400.
PY - 1993/9
Y1 - 1993/9
N2 - This prospective study measured the incidence of Leishmania infection, by Leishmanin skin test (LST) conversion, and leishmaniasis, by new acquisition of lesions, in a Leishmania braziliensis endemic area of Colombia, during 7243 person-years. The incidence rate of infection and leishmaniasis varied greatly by village, ranging from 2.8 to 23.0/100 person-years and 0.0 to 20.4/1000 person-years, respectively. Adult males experienced greater rates of both infection and leishmaniasis. Most primary infections (91%) were subclinical initially. Typical scars were predictive of subsequent leishmaniases both for persons initially LST-reactive (risk ratio = 11.3, P =.003) and for those initially nonreactive (risk ratio = 3.2, P =.02). Only one-third of the diagnosed leishmaniasis cases (24/77) were due to newly acquired infections in naive hosts. The relative contribution of existing lesions, recurrences, and new infections to the burden of disease should be considered in the planning of leishmaniasis control programs.
AB - This prospective study measured the incidence of Leishmania infection, by Leishmanin skin test (LST) conversion, and leishmaniasis, by new acquisition of lesions, in a Leishmania braziliensis endemic area of Colombia, during 7243 person-years. The incidence rate of infection and leishmaniasis varied greatly by village, ranging from 2.8 to 23.0/100 person-years and 0.0 to 20.4/1000 person-years, respectively. Adult males experienced greater rates of both infection and leishmaniasis. Most primary infections (91%) were subclinical initially. Typical scars were predictive of subsequent leishmaniases both for persons initially LST-reactive (risk ratio = 11.3, P =.003) and for those initially nonreactive (risk ratio = 3.2, P =.02). Only one-third of the diagnosed leishmaniasis cases (24/77) were due to newly acquired infections in naive hosts. The relative contribution of existing lesions, recurrences, and new infections to the burden of disease should be considered in the planning of leishmaniasis control programs.
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U2 - 10.1093/infdis/168.3.699
DO - 10.1093/infdis/168.3.699
M3 - Article
C2 - 8354912
AN - SCOPUS:0027235941
SN - 0022-1899
VL - 168
SP - 699
EP - 708
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 3
ER -