TY - JOUR
T1 - Epidemiology of Cutaneous Leishmaniasis in Colombia
T2 - Environmental and Behavioral Risk Factors for Infection, Clinical Manifestations, and Pathogenicity
AU - Weigle, Kristen A.
AU - Santrich, Cecilia
AU - Martinez, Fernando
AU - Valderrama, Liliana
AU - Saravia, Nancy G.
AU - Weigle, Kristen A.
AU - Santrich, Cecilia
AU - Martinez, Fernando
AU - Valderrama, Liliana
AU - Saravia, Nancy G.
N1 - Funding Information:
Received 22 October 1992; revised 28 May 1993. Presented in part: Latin American Congress of Tropical Medicine, Mexico City, May 1990 (abstract 118); International Development Research Centre workshop on the control of leishmaniasis. Merida. Mexico. November 1991. Written informed consent was obtained from the participants or. in the case of minors, their parents or guardians. Human experimental guidelines of the US Department of Health and Human Services and those of the Ethical Review Board of the Fundacion para la Educacion Superior were followed. Grant support: International Development Research Centre of Canada (project 3-p-85-0279): National Institutes of Health (AI-16315): United Nations Development Programme/World Health Organization Special Programme for Research and Training in Tropical Diseases (840336): Mellon Foundation (to K.A.W.). Reprints or correspondence: Dr. Kristen A. Weigle. Department ofEpidemiology. CB 7400, University of North Carolina. Chapel Hill. NC 27599-7400.
PY - 1993/9
Y1 - 1993/9
N2 - Through a longitudinal, active surveillance for Leishmania (Viannia) braziliensis and Leishmania (Viannia) panamensis infection and lesions on the Pacific Coast of Colombia, risk factors for infection (leishmanin skin test conversion), leishmaniallesions, and pathogenicity were examined. Risk factor information was obtained prior to and independently of case ascertainment. Similar factors were associated with acquisition ofinfection and ofleishmaniasis, including male sex, age > 10 years, and farming occupation. The behaviors of entering the forest after sunset, hunting, and lumbering were most strongly associated with Leishmania infection independently ofage, sex, and farming occupation. Environmental conditions associated with infection, including tall trees near the home, home located > 15 m from the nearest neighbor, and floor and roof made of open material, were less strong predictors of risk. Pathogenicity, the risk of lesion given a new infection, was reduced in those > 30 years of age and those entering the forest frequently.
AB - Through a longitudinal, active surveillance for Leishmania (Viannia) braziliensis and Leishmania (Viannia) panamensis infection and lesions on the Pacific Coast of Colombia, risk factors for infection (leishmanin skin test conversion), leishmaniallesions, and pathogenicity were examined. Risk factor information was obtained prior to and independently of case ascertainment. Similar factors were associated with acquisition ofinfection and ofleishmaniasis, including male sex, age > 10 years, and farming occupation. The behaviors of entering the forest after sunset, hunting, and lumbering were most strongly associated with Leishmania infection independently ofage, sex, and farming occupation. Environmental conditions associated with infection, including tall trees near the home, home located > 15 m from the nearest neighbor, and floor and roof made of open material, were less strong predictors of risk. Pathogenicity, the risk of lesion given a new infection, was reduced in those > 30 years of age and those entering the forest frequently.
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U2 - 10.1093/infdis/168.3.709
DO - 10.1093/infdis/168.3.709
M3 - Article
C2 - 8354913
AN - SCOPUS:0027181313
SN - 0022-1899
VL - 168
SP - 709
EP - 714
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 3
ER -