Epidemiology of HPV-associated oropharyngeal cancer

Kristen B. Pytynia; Kristina R. Dahlstrom; Erich M. Sturgis

doi:10.1016/j.oraloncology.2013.12.019

Epidemiology of HPV-associated oropharyngeal cancer

Kristen B. Pytynia, Kristina R. Dahlstrom, Erich M. Sturgis

Head & Neck Surgery

Research output: Contribution to journal › Review article › peer-review

369 Scopus citations

Abstract

Squamous cell carcinoma of the oropharynx is increasing in incidence in epidemic proportion. This site specific increase in incidence is due to an increase in human papillomavirus (HPV)-related squamous cell carcinoma, while the incidence of tobacco related squamous cell carcinoma is decreasing. In particular, the incidence of HPV-related oropharyngeal squamous cell carcinoma (OPSCC) is increased among middle aged white men, and sexual behavior is a risk factor. HPV-related oropharyngeal squamous cell carcinoma represents a growing etiologically distinct subset of head and neck cancers with unique epidemiological, clinical, and molecular characteristics that differ from those of HPV-unassociated cancers. In this review, we discuss the epidemiology of HPV-related OPSCC, the prevalence of oral/oropharyngeal HPV infection, and efforts aimed at reducing the incidence of HPV-related OPSCC.

Original language	English (US)
Pages (from-to)	380-386
Number of pages	7
Journal	Oral Oncology
Volume	50
Issue number	5
DOIs	https://doi.org/10.1016/j.oraloncology.2013.12.019
State	Published - May 2014

Keywords

Epidemiology
Human papillomavirus
Oropharyngeal cancer

ASJC Scopus subject areas

Oral Surgery
Oncology
Cancer Research

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10.1016/j.oraloncology.2013.12.019

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title = "Epidemiology of HPV-associated oropharyngeal cancer",

abstract = "Squamous cell carcinoma of the oropharynx is increasing in incidence in epidemic proportion. This site specific increase in incidence is due to an increase in human papillomavirus (HPV)-related squamous cell carcinoma, while the incidence of tobacco related squamous cell carcinoma is decreasing. In particular, the incidence of HPV-related oropharyngeal squamous cell carcinoma (OPSCC) is increased among middle aged white men, and sexual behavior is a risk factor. HPV-related oropharyngeal squamous cell carcinoma represents a growing etiologically distinct subset of head and neck cancers with unique epidemiological, clinical, and molecular characteristics that differ from those of HPV-unassociated cancers. In this review, we discuss the epidemiology of HPV-related OPSCC, the prevalence of oral/oropharyngeal HPV infection, and efforts aimed at reducing the incidence of HPV-related OPSCC.",

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author = "Pytynia, {Kristen B.} and Dahlstrom, {Kristina R.} and Sturgis, {Erich M.}",

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T1 - Epidemiology of HPV-associated oropharyngeal cancer

AU - Pytynia, Kristen B.

AU - Dahlstrom, Kristina R.

AU - Sturgis, Erich M.

PY - 2014/5

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N2 - Squamous cell carcinoma of the oropharynx is increasing in incidence in epidemic proportion. This site specific increase in incidence is due to an increase in human papillomavirus (HPV)-related squamous cell carcinoma, while the incidence of tobacco related squamous cell carcinoma is decreasing. In particular, the incidence of HPV-related oropharyngeal squamous cell carcinoma (OPSCC) is increased among middle aged white men, and sexual behavior is a risk factor. HPV-related oropharyngeal squamous cell carcinoma represents a growing etiologically distinct subset of head and neck cancers with unique epidemiological, clinical, and molecular characteristics that differ from those of HPV-unassociated cancers. In this review, we discuss the epidemiology of HPV-related OPSCC, the prevalence of oral/oropharyngeal HPV infection, and efforts aimed at reducing the incidence of HPV-related OPSCC.

AB - Squamous cell carcinoma of the oropharynx is increasing in incidence in epidemic proportion. This site specific increase in incidence is due to an increase in human papillomavirus (HPV)-related squamous cell carcinoma, while the incidence of tobacco related squamous cell carcinoma is decreasing. In particular, the incidence of HPV-related oropharyngeal squamous cell carcinoma (OPSCC) is increased among middle aged white men, and sexual behavior is a risk factor. HPV-related oropharyngeal squamous cell carcinoma represents a growing etiologically distinct subset of head and neck cancers with unique epidemiological, clinical, and molecular characteristics that differ from those of HPV-unassociated cancers. In this review, we discuss the epidemiology of HPV-related OPSCC, the prevalence of oral/oropharyngeal HPV infection, and efforts aimed at reducing the incidence of HPV-related OPSCC.

KW - Epidemiology

KW - Human papillomavirus

KW - Oropharyngeal cancer

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JO - Oral Oncology

JF - Oral Oncology

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Epidemiology of HPV-associated oropharyngeal cancer

Abstract

Keywords

ASJC Scopus subject areas

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