TY - JOUR
T1 - Epidermodysplasia verruciformis in the setting of graft-versus-host disease
AU - Kunishige, Joy H.
AU - Hymes, Sharon R.
AU - Madkan, Vandana
AU - Wyatt, Angela J.
AU - Uptmore, David
AU - Lazar, Alexander J.F.
AU - Giralt, Sergio
AU - Rady, Peter
AU - Tyring, Stephen
PY - 2007/11
Y1 - 2007/11
N2 - We report a case of epidermodysplasia verruciformis (EV)-like lesions in a patient with graft-versus-host disease after peripheral blood stem cell transplantation from his HLA-matched brother. The patient presented with a diffuse papular eruption that was clinically consistent with graft-versus-host disease; however, histopathology demonstrated viral cytopathic changes and polymerase chain reaction confirmed EV human papillomavirus types 8 and 20. Repeated biopsy specimen showed both human papillomavirus cytopathic effect and graft-versus-host disease, and further workup revealed ocular and hepatic involvement. This progressed to a lupuslike syndrome with lichenoid, violaceous, flat-topped papules in a malar distribution and positive antinuclear autoantibodies. Although EV-like lesions have been reported in patients who are immunocompromised, the incidence is low, and may be linked to EV-related haplotypes.
AB - We report a case of epidermodysplasia verruciformis (EV)-like lesions in a patient with graft-versus-host disease after peripheral blood stem cell transplantation from his HLA-matched brother. The patient presented with a diffuse papular eruption that was clinically consistent with graft-versus-host disease; however, histopathology demonstrated viral cytopathic changes and polymerase chain reaction confirmed EV human papillomavirus types 8 and 20. Repeated biopsy specimen showed both human papillomavirus cytopathic effect and graft-versus-host disease, and further workup revealed ocular and hepatic involvement. This progressed to a lupuslike syndrome with lichenoid, violaceous, flat-topped papules in a malar distribution and positive antinuclear autoantibodies. Although EV-like lesions have been reported in patients who are immunocompromised, the incidence is low, and may be linked to EV-related haplotypes.
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U2 - 10.1016/j.jaad.2006.04.035
DO - 10.1016/j.jaad.2006.04.035
M3 - Article
C2 - 17938030
AN - SCOPUS:35148888647
SN - 0190-9622
VL - 57
SP - S78-S80
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
IS - 5 SUPPL.
ER -