@inbook{7122b48804e24d70baa21a6dd965c98b,
title = "Epigenetic consequences of Epstein–Barr virus infection",
abstract = "The biphasic nature of the Epstein–Barr virus (EBV) life cycle is tightly regulated by epigenetic modifications. Silencing of viral gene expression associated with latency is accompanied by repressive chromatin modifications and DNA methylation. Latency is integral to the lifelong persistence of EBV, yet persistence also relies on viral replication and virus production for infection of na{\"i}ve hosts. Thus, EBV can overcome and disrupt the repressive epigenetic environment of the latent viral genomes. Viral modulators of the host epigenetic machinery are not only involved in establishing the latent and lytic viral epigenetic states but also reprogram the host epigenome in ways that are likely beneficial to the virus, but can carry long term consequences to the host. Here, we will review epigenetic aspects of EBV life cycle control and consequences to the host cell.",
keywords = "Carcinoma, Chromatin, DNA methylation, EBV, Epstein–Barr virus, Latency, Lymphoma, Reactivation",
author = "Birdwell, {Christine E.} and Krista Queen and Scott, {Rona S.}",
note = "Funding Information: We would like to acknowledge all the excellent work that we could not cite due to space constraints. This work was supported by funding from the NIDCR 1R01DE025565 to RSS and a predoctoral fellowship to CEB. Publisher Copyright: {\textcopyright} 2017, Springer International Publishing AG.",
year = "2017",
doi = "10.1007/978-3-319-55021-3_4",
language = "English (US)",
series = "Epigenetics and Human Health",
publisher = "Springer Verlag",
number = "9783319550190",
pages = "65--87",
booktitle = "Epigenetics and Human Health",
edition = "9783319550190",
}