TY - JOUR
T1 - Epithelial growth factor receptor-activated nuclear factor κb signaling and its role in epithelial growth factor receptor-associated tumors
AU - Pan, Deng
AU - Lin, Xin
PY - 2013/11
Y1 - 2013/11
N2 - Dysregulated epithelial growth factor receptor (EGFR) signaling is directly associated with a number of cancers, such as brain, lung, and breast cancer. The downstream signaling pathways activated by EGFR have been extensively studied, such as PI3K/AKT pathway, MAPK (mitogen-activated protein kinase) pathway, and STAT (signal transducer and activator of transcription) pathway. There are growing numbers of evidence suggesting that EGFR activates nuclear factor κB (NF-κB), which is a key transcription factor controlling a variety of cellular functions. However, relatively less is known about the signal transduction mechanism that links EGFR to NF-κB activation. Here, we discuss recent progress in EGFR-induced NF-κB pathways, including the identification of CARMA3-Bcl10-MALT1 complex and protein kinase C[Latin Small Letter Open E] as 2 essential signaling components linking EGFR to the activation of IκBα kinase. In addition, we discuss the multifunctional roles of NF-κB in EGFR-associated tumors, including proliferation, tumor invasiveness, metabolism, tumor-promoting microenvironment, and EGFR tyrosine kinase inhibitor resistance.
AB - Dysregulated epithelial growth factor receptor (EGFR) signaling is directly associated with a number of cancers, such as brain, lung, and breast cancer. The downstream signaling pathways activated by EGFR have been extensively studied, such as PI3K/AKT pathway, MAPK (mitogen-activated protein kinase) pathway, and STAT (signal transducer and activator of transcription) pathway. There are growing numbers of evidence suggesting that EGFR activates nuclear factor κB (NF-κB), which is a key transcription factor controlling a variety of cellular functions. However, relatively less is known about the signal transduction mechanism that links EGFR to NF-κB activation. Here, we discuss recent progress in EGFR-induced NF-κB pathways, including the identification of CARMA3-Bcl10-MALT1 complex and protein kinase C[Latin Small Letter Open E] as 2 essential signaling components linking EGFR to the activation of IκBα kinase. In addition, we discuss the multifunctional roles of NF-κB in EGFR-associated tumors, including proliferation, tumor invasiveness, metabolism, tumor-promoting microenvironment, and EGFR tyrosine kinase inhibitor resistance.
KW - Downstream Signaling Pathways
KW - Egfr (Epithelial Growth Factor Receptor) Signaling
KW - Mapk Pathway
KW - Nuclear Factor κB
KW - Pi3K/Akt Pathway
KW - Stat Pathway
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UR - http://www.scopus.com/inward/citedby.url?scp=84889003724&partnerID=8YFLogxK
U2 - 10.1097/PPO.0000000000000001
DO - 10.1097/PPO.0000000000000001
M3 - Review article
C2 - 24270344
AN - SCOPUS:84889003724
SN - 1528-9117
VL - 19
SP - 461
EP - 467
JO - Cancer Journal (United States)
JF - Cancer Journal (United States)
IS - 6
ER -