Abstract
Epstein-Barr virus-positive (EBV-positive) diffuse large B-cell lymphoma (DLBCL) of the elderly is a newly described lymphoproliferative disorder recently included as a "provisional" entity in the most current WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. The objective of this review is to provide a thorough and current summary of the existing knowledge of this subtype of DLBCL. We will review and discuss the incidence of EBV expression in DLBCL, the pathogenesis behind EBV-driven malignant transformation of B cells, the different EBV latency patterns associated with DLBCL, the distinct pathologic characteristics of EBV-positive DLBCL, the potential predictive and prognostic value of EBV tumoral status in patients with DLBCL, and potential strategies for the treatment of this rare entity, which is characterized by a suboptimal response to therapy and poor survival rate.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 87-96 |
| Number of pages | 10 |
| Journal | Oncologist |
| Volume | 16 |
| Issue number | 1 |
| DOIs | |
| State | Published - 2011 |
Keywords
- DLBCL
- Diffuse large b-cell lymphoma
- EBV
- Elderly
- Epstein-barr virus
- Review
ASJC Scopus subject areas
- Oncology
- Cancer Research