Epstein–Barr virus-associated gastric cancer: disease that requires special approach

Ekaterina Ignatova; Daria Seriak; Mikhail Fedyanin; Alexey Tryakin; Ilya Pokataev; Sofia Menshikova; Yuliya Vakhabova; Ksenia Smirnova; Sergey Tjulandin; Jaffer A. Ajani

doi:10.1007/s10120-020-01095-z

Epstein–Barr virus-associated gastric cancer: disease that requires special approach

Ekaterina Ignatova, Daria Seriak, Mikhail Fedyanin, Alexey Tryakin, Ilya Pokataev, Sofia Menshikova, Yuliya Vakhabova, Ksenia Smirnova, Sergey Tjulandin, Jaffer A. Ajani

GI Medical Oncology

Research output: Contribution to journal › Review article › peer-review

26 Scopus citations

Abstract

Epstein–Barr virus-associated gastric cancer [EBV-associated GC, EBV(+) GC] is a distinct molecular subtype of gastrointestinal (GI) cancers. It accounts for up to 10% of all molecular subtypes of gastric cancer (GC). It has unique genetic and epigenetic features, which determine its definitive phenotype with male and younger age predominance, proximal stomach localization, and diffuse adenocarcinoma histology. EBV(+) GC also has a unique epigenetic profile and mutational status with frequent mutations of PIK3CA, ARID1A and BCOR, and PD-L1 and PD-L2 amplifications, as well. The aim of this review is to highlight clinical significance of EBV(+) GC and prognostic role of EBV infection, and to determine potentially appropriate drug therapy for this disease.

Original language	English (US)
Pages (from-to)	951-960
Number of pages	10
Journal	Gastric Cancer
Volume	23
Issue number	6
DOIs	https://doi.org/10.1007/s10120-020-01095-z
State	Published - Nov 1 2020

Keywords

Epstein–Barr virus
Epstein–Barr virus infection
Gastric cancer
Oesophago-gastric cancer
Stomach cancer

ASJC Scopus subject areas

Oncology
Gastroenterology
Cancer Research

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title = "Epstein–Barr virus-associated gastric cancer: disease that requires special approach",

abstract = "Epstein–Barr virus-associated gastric cancer [EBV-associated GC, EBV(+) GC] is a distinct molecular subtype of gastrointestinal (GI) cancers. It accounts for up to 10% of all molecular subtypes of gastric cancer (GC). It has unique genetic and epigenetic features, which determine its definitive phenotype with male and younger age predominance, proximal stomach localization, and diffuse adenocarcinoma histology. EBV(+) GC also has a unique epigenetic profile and mutational status with frequent mutations of PIK3CA, ARID1A and BCOR, and PD-L1 and PD-L2 amplifications, as well. The aim of this review is to highlight clinical significance of EBV(+) GC and prognostic role of EBV infection, and to determine potentially appropriate drug therapy for this disease.",

keywords = "Epstein–Barr virus, Epstein–Barr virus infection, Gastric cancer, Oesophago-gastric cancer, Stomach cancer",

author = "Ekaterina Ignatova and Daria Seriak and Mikhail Fedyanin and Alexey Tryakin and Ilya Pokataev and Sofia Menshikova and Yuliya Vakhabova and Ksenia Smirnova and Sergey Tjulandin and Ajani, {Jaffer A.}",

note = "Publisher Copyright: {\textcopyright} 2020, The International Gastric Cancer Association and The Japanese Gastric Cancer Association.",

year = "2020",

month = nov,

day = "1",

doi = "10.1007/s10120-020-01095-z",

language = "English (US)",

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journal = "Gastric Cancer",

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T1 - Epstein–Barr virus-associated gastric cancer

T2 - disease that requires special approach

AU - Ignatova, Ekaterina

AU - Seriak, Daria

AU - Fedyanin, Mikhail

AU - Tryakin, Alexey

AU - Pokataev, Ilya

AU - Menshikova, Sofia

AU - Vakhabova, Yuliya

AU - Smirnova, Ksenia

AU - Tjulandin, Sergey

AU - Ajani, Jaffer A.

PY - 2020/11/1

Y1 - 2020/11/1

N2 - Epstein–Barr virus-associated gastric cancer [EBV-associated GC, EBV(+) GC] is a distinct molecular subtype of gastrointestinal (GI) cancers. It accounts for up to 10% of all molecular subtypes of gastric cancer (GC). It has unique genetic and epigenetic features, which determine its definitive phenotype with male and younger age predominance, proximal stomach localization, and diffuse adenocarcinoma histology. EBV(+) GC also has a unique epigenetic profile and mutational status with frequent mutations of PIK3CA, ARID1A and BCOR, and PD-L1 and PD-L2 amplifications, as well. The aim of this review is to highlight clinical significance of EBV(+) GC and prognostic role of EBV infection, and to determine potentially appropriate drug therapy for this disease.

AB - Epstein–Barr virus-associated gastric cancer [EBV-associated GC, EBV(+) GC] is a distinct molecular subtype of gastrointestinal (GI) cancers. It accounts for up to 10% of all molecular subtypes of gastric cancer (GC). It has unique genetic and epigenetic features, which determine its definitive phenotype with male and younger age predominance, proximal stomach localization, and diffuse adenocarcinoma histology. EBV(+) GC also has a unique epigenetic profile and mutational status with frequent mutations of PIK3CA, ARID1A and BCOR, and PD-L1 and PD-L2 amplifications, as well. The aim of this review is to highlight clinical significance of EBV(+) GC and prognostic role of EBV infection, and to determine potentially appropriate drug therapy for this disease.

KW - Epstein–Barr virus

KW - Epstein–Barr virus infection

KW - Gastric cancer

KW - Oesophago-gastric cancer

KW - Stomach cancer

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U2 - 10.1007/s10120-020-01095-z

DO - 10.1007/s10120-020-01095-z

M3 - Review article

C2 - 32514646

AN - SCOPUS:85086160701

SN - 1436-3291

VL - 23

SP - 951

EP - 960

JO - Gastric Cancer

JF - Gastric Cancer

IS - 6

ER -

Epstein–Barr virus-associated gastric cancer: disease that requires special approach

Abstract

Keywords

ASJC Scopus subject areas

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