Abstract
Eleven women with advanced ovarian cancer were treated with a sequential and combined hormonal regimen designed to induce and bind tumor progesterone receptors. Two partial responses were seen, and two patients with a recent history of rapid tumor progression achieved disease stabilization. One patient experienced a transient ischemic cerebrovascular episode while on therapy, and a second patient discontinued therapy because of nausea. The regimen was able to induce progesterone receptors in vivo. One patient had no progesterone receptor in a pretreatment tumor biopsy, but did have a high titer of receptors after her first cycle of treatment.
Original language | English (US) |
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Pages (from-to) | 352-359 |
Number of pages | 8 |
Journal | Gynecologic oncology |
Volume | 16 |
Issue number | 3 |
DOIs | |
State | Published - Dec 1983 |
ASJC Scopus subject areas
- Oncology
- Obstetrics and Gynecology