TY - JOUR
T1 - Estrogenic activity of DDT
T2 - Estrogen-receptor profiles and the responses of individual uterine cell types following o, p’-DDT administration
AU - Robison, Alice K.
AU - Schmidt, Waldemar A.
AU - Stancel, George M.
N1 - Funding Information:
This study was supported by National Institutes of Health grant HD-08615. A. K. Robison was the recipient of National Institute of Environmental Health Science traineeship ES-07090. Present address for A. K. Robison is Department of Medicine, Washington University School of Medicine, Louis, Missouri 63110. The authors wish to thank Ruby Dotson for assistance with the preparation of this manuscript. Requests for reprints should be sent to George M. Stancel, Department of Pharmacology, University of Texas Medical School, P.O. Box 20708, Houston, Texas 77025.
PY - 1985/1/1
Y1 - 1985/1/1
N2 - The administration of o, p’-dichlorodiphenyltrichloroethane (o, p’-DDT) to immature rats stimulates DNA synthesis and cell division in the uterine luminal epithelium (LE), stroma (S), and myometrium (M). The time course of DNA synthesis/cell division in the S and M is similar following administration of o, p’-DDT or 17 β-estradiol, but the maximum response following pesticide treatment is only 70% of that produced by the hormone. In the LE both compounds yield the same maximum response, but the time course of DNA synthesis/cell division is delayed following o, p’-DDT administration relative to 17 β-estradiol treatment. The patterns of estrogen receptor retention in uterine nuclei following o, p’-DDT administration are prolonged relative to those observed after 17 β-estradiol treatment. o, p’-DDT thus produces the uterine hyperplasia characteristic of estrogens, but the magnitude and timing of the response is dependent on the specific cell type observed and is different from that produced by estradiol.
AB - The administration of o, p’-dichlorodiphenyltrichloroethane (o, p’-DDT) to immature rats stimulates DNA synthesis and cell division in the uterine luminal epithelium (LE), stroma (S), and myometrium (M). The time course of DNA synthesis/cell division in the S and M is similar following administration of o, p’-DDT or 17 β-estradiol, but the maximum response following pesticide treatment is only 70% of that produced by the hormone. In the LE both compounds yield the same maximum response, but the time course of DNA synthesis/cell division is delayed following o, p’-DDT administration relative to 17 β-estradiol treatment. The patterns of estrogen receptor retention in uterine nuclei following o, p’-DDT administration are prolonged relative to those observed after 17 β-estradiol treatment. o, p’-DDT thus produces the uterine hyperplasia characteristic of estrogens, but the magnitude and timing of the response is dependent on the specific cell type observed and is different from that produced by estradiol.
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U2 - 10.1080/15287398509530758
DO - 10.1080/15287398509530758
M3 - Article
C2 - 4087314
AN - SCOPUS:0022320032
SN - 0098-4108
VL - 16
SP - 493
EP - 508
JO - Journal of Toxicology and Environmental Health
JF - Journal of Toxicology and Environmental Health
IS - 3-4
ER -