TY - JOUR
T1 - ESX1L, a novel X chromosome-linked human homeobox gene expressed in the placenta and testis
AU - Fohn, Laurel E.
AU - Behringer, Richard R.
N1 - Funding Information:
We thank Yuanhao Li and Qiyong Hu for helpful suggestions. The DNA Sequencing and Analysis Facility of the M. D. Anderson Cancer Center is funded by National Cancer Institute Grant CA16672. These studies were supported by National Institutes of Health Grant HD30284 to R.R.B. and by funds provided by the Barnts Family.
PY - 2001/5/15
Y1 - 2001/5/15
N2 - A novel human homeobox gene related to the mouse Esx1 homeobox gene, which we have designated ESXR1, has been identified. ESXR1 and Esx1 share 65% identity within their homeodomains and have glutamic acid-rich and proline-rich N- and C-terminal regions, respectively. Unlike Esx1, ESXR1 contains 12 repeats of a unique nine amino acid motif, PPMAP(V/L)PPG, located C-terminal to the homeodomain. The general exon-intron structures of ESXR1 and Esx1 appear to be conserved. ESXR1 has been localized to human Xq22.1-q22.3, the same region of synteny shared by the map position of Esx1. ESXR1 expression appears to be restricted to the placenta and testis, the tissues in which Esx1 is also expressed. These data suggest that ESXR1 may be the orthologne of Esx1. The findings that there are similarities between ESXR1 and Esx1, yet differences between their encoded products, are consistent with the idea that placental genes evolve rapidly between mammalian species.
AB - A novel human homeobox gene related to the mouse Esx1 homeobox gene, which we have designated ESXR1, has been identified. ESXR1 and Esx1 share 65% identity within their homeodomains and have glutamic acid-rich and proline-rich N- and C-terminal regions, respectively. Unlike Esx1, ESXR1 contains 12 repeats of a unique nine amino acid motif, PPMAP(V/L)PPG, located C-terminal to the homeodomain. The general exon-intron structures of ESXR1 and Esx1 appear to be conserved. ESXR1 has been localized to human Xq22.1-q22.3, the same region of synteny shared by the map position of Esx1. ESXR1 expression appears to be restricted to the placenta and testis, the tissues in which Esx1 is also expressed. These data suggest that ESXR1 may be the orthologne of Esx1. The findings that there are similarities between ESXR1 and Esx1, yet differences between their encoded products, are consistent with the idea that placental genes evolve rapidly between mammalian species.
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U2 - 10.1006/geno.2001.6532
DO - 10.1006/geno.2001.6532
M3 - Article
C2 - 11374906
AN - SCOPUS:0035872834
SN - 0888-7543
VL - 74
SP - 105
EP - 108
JO - Genomics
JF - Genomics
IS - 1
ER -