Ether phospholipids govern ferroptosis

Hyemin Lee; Li Zhuang; Boyi Gan

doi:10.1016/j.jgg.2021.05.003

Ether phospholipids govern ferroptosis

Hyemin Lee, Li Zhuang, Boyi Gan

Experimental Radiation Oncology

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Ferroptosis is a cell death modality triggered by excessive lipid peroxidation. Two recent studies (Zou et al., 2020; Cui et al., 2021) not only reveal critical roles of ether-linked phospholipids as an additional source for providing polyunsaturated fatty acid-containing phospholipids in driving ferroptosis but also suggest a context-dependent role of TMEM189-mediated vinyl-ether phospholipid (plasmalogen) synthesis in ferroptosis.

Original language	English (US)
Pages (from-to)	517-519
Number of pages	3
Journal	Journal of Genetics and Genomics
Volume	48
Issue number	7
DOIs	https://doi.org/10.1016/j.jgg.2021.05.003
State	Published - Jul 20 2021

Keywords

Ether phospholipids
Ferroptosis
Lipid peroxidation
Plasmalogen
TMEM189

ASJC Scopus subject areas

Molecular Biology
Genetics

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10.1016/j.jgg.2021.05.003

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title = "Ether phospholipids govern ferroptosis",

abstract = "Ferroptosis is a cell death modality triggered by excessive lipid peroxidation. Two recent studies (Zou et al., 2020; Cui et al., 2021) not only reveal critical roles of ether-linked phospholipids as an additional source for providing polyunsaturated fatty acid-containing phospholipids in driving ferroptosis but also suggest a context-dependent role of TMEM189-mediated vinyl-ether phospholipid (plasmalogen) synthesis in ferroptosis.",

keywords = "Ether phospholipids, Ferroptosis, Lipid peroxidation, Plasmalogen, TMEM189",

author = "Hyemin Lee and Li Zhuang and Boyi Gan",

note = "Publisher Copyright: {\textcopyright} 2021 Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China",

year = "2021",

month = jul,

day = "20",

doi = "10.1016/j.jgg.2021.05.003",

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T1 - Ether phospholipids govern ferroptosis

AU - Lee, Hyemin

AU - Zhuang, Li

AU - Gan, Boyi

PY - 2021/7/20

Y1 - 2021/7/20

N2 - Ferroptosis is a cell death modality triggered by excessive lipid peroxidation. Two recent studies (Zou et al., 2020; Cui et al., 2021) not only reveal critical roles of ether-linked phospholipids as an additional source for providing polyunsaturated fatty acid-containing phospholipids in driving ferroptosis but also suggest a context-dependent role of TMEM189-mediated vinyl-ether phospholipid (plasmalogen) synthesis in ferroptosis.

AB - Ferroptosis is a cell death modality triggered by excessive lipid peroxidation. Two recent studies (Zou et al., 2020; Cui et al., 2021) not only reveal critical roles of ether-linked phospholipids as an additional source for providing polyunsaturated fatty acid-containing phospholipids in driving ferroptosis but also suggest a context-dependent role of TMEM189-mediated vinyl-ether phospholipid (plasmalogen) synthesis in ferroptosis.

KW - Ether phospholipids

KW - Ferroptosis

KW - Lipid peroxidation

KW - Plasmalogen

KW - TMEM189

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M3 - Article

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AN - SCOPUS:85109104883

SN - 1673-8527

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EP - 519

JO - Journal of Genetics and Genomics

JF - Journal of Genetics and Genomics

IS - 7

ER -

Ether phospholipids govern ferroptosis

Abstract

Keywords

ASJC Scopus subject areas

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