@article{d4da67698fe24b5b91729158e2f47378,
title = "Etiology and pathogenesis of epithelial ovarian cancer",
abstract = "Ovarian cancer is complex disease composed of different histological grades and types. However, the underlying molecular mechanisms involved in the development of different phenotypes remain largely unknown. Epidemiological studies identified multiple exogenous and endogenous risk factors for ovarian cancer development. Among them, an inflammatory stromal microenvironment seems to play a critical role in the initiation of the disease. The interaction between such a microenvironment, genetic polymorphisms, and different epithelial components such as endosalpingiosis, endometriosis, and ovarian inclusion cyst in the ovarian cortex may induce different genetic changes identified in the epithelial component of different histological types of ovarian tumors. Genetic studies on different histological grades and types provide insight into the pathogenetic pathways for the development of different disease phenotypes. However, the link between all these genetic changes and the etiological factors remains to be established.",
keywords = "Inflammation, Microenvironment, Ovarian cancer, Pathogenesis",
author = "Mok, {Samuel C.} and Joseph Kwong and Welch, {William R.} and Goli Samimi and Laurent Ozbun and Tomas Bonome and Birrer, {Michael J.} and Berkowitz, {Ross S.} and Wong, {Kwong Kwok}",
note = "Funding Information: Mok Samuel C. scmok@rics.bwh.harvard.edu 1, 2 Kwong Joseph 1 Welch William R. 3 Samimi Goli 4, 5 Ozbun Laurent 4 Bonome Tomas 4 Birrer Michael J. 4 Berkowitz Ross S. 1, 2 Wong Kwong-Kwok 6 Department of Obstetrics Gynecology and Reproductive Biology Laboratory of Gynecologic Oncology Brigham and Women{\textquoteright}s Hospital Harvard Medical School Boston MA 02115 USA Gillette Center For Women{\textquoteright}s Cancer Dana-Farber/Harvard Cancer Center Boston MA 02115 USA Department of Pathology Brigham and Women{\textquoteright}s Hospital Harvard Medical School Boston, MA 02115 USA Cell and Cancer Biology Branch Center for Cancer Research National Cancer Institute Bethesda MD 20892 USA Cancer Prevention Fellowship Program Office of Preventative Oncology Division of Cancer Prevention Bethesda MD 20892 USA Department of Gynecologic Oncology The University of Texas M. D. Anderson Cancer Center Houston TX 77030 USA 2007 5 6 2013 23 5-6 367 376 9 11 2007 9 11 2007 2007 Copyright {\textcopyright} 2007 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Ovarian cancer is complex disease composed of different histological grades and types. However, the underlying molecular mechanisms involved in the development of different phenotypes remain largely unknown. Epidemiological studies identified multiple exogenous and endogenous risk factors for ovarian cancer development. Among them, an inflammatory stromal microenvironment seems to play a critical role in the initiation of the disease. The interaction between such a microenvironment, genetic polymorphisms, and different epithelial components such as endosalpingiosis, endometriosis, and ovarian inclusion cyst in the ovarian cortex may induce different genetic changes identified in the epithelial component of different histological types of ovarian tumors. Genetic studies on different histological grades and types provide insight into the pathogenetic pathways for the development of different disease phenotypes. However, the link between all these genetic changes and the etiological factors remains to be established. Ovarian cancer microenvironment inflammation pathogenesis http://dx.doi.org/10.13039/100000002 National Institutes of Health R33CA103595 http://dx.doi.org/10.13039/100000002 National Institutes of Health CA105009 The Gillette Center For Women{\textquoteright}s Cancer Adler Foundation Edgar Astrove Fund http://dx.doi.org/10.13039/100001282 Ovarian Cancer Research Fund The Morse Family Fund The Natalie Pihl Fund ",
year = "2007",
doi = "10.1155/2007/474320",
language = "English (US)",
volume = "23",
pages = "367--376",
journal = "Disease markers",
issn = "0278-0240",
publisher = "IOS Press",
number = "5-6",
}