Abstract
Purpose: Li-Fraumeni syndrome (LFS) is associated with p53germline mutations, and carriers are at increased risk for multiple primary cancers. We evaluated outcomes following the administration of a video-based decision aid (DA) prior to clinical p53 genetic counseling and testing among persons who had previously participated in cancer genetics research. Methods: Fifty-seven individuals at risk for a known p53 mutation completed baseline and post-DA measures of psychological outcomes, plus knowledge and attitudes regarding p53 genetic testing. Counseling and testing uptake also was recorded. Results: At baseline, multivariate analysis showed that greater testing intention was associated with lower decisional conflict (P < 0.01). Compared with baseline data, multivariate analyses of post-DA outcomes showed that knowledge about LFS and genetic testing increased and decisional conflict related to testing decreased (P < 0.001). Mean cancer worries scores decreased among all participants (P < 0.001), and mean depression scores decreased for males (P < 0.05). Thirty-nine (68%) completed pre-test genetic counseling and 23 (40%) subsequently gave a blood sample for clinical genetic testing. Conclusion: This intervention was useful as an initial outreach and educational method for families considering p53 genetic testing, and may improve knowledge about LFS as well as psychological outcomes.
Original language | English (US) |
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Pages (from-to) | 226-233 |
Number of pages | 8 |
Journal | Genetics in Medicine |
Volume | 8 |
Issue number | 4 |
DOIs | |
State | Published - Apr 2006 |
Keywords
- Decision aid
- Genetic counseling
- Genetic testing
- Psychosocial
- p53
ASJC Scopus subject areas
- Genetics(clinical)
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Assessment, Intervention and Measurement Population Shared Resources
Susan K Peterson (Director) & Karen M Basen-Engquist (Director)
Behavioral ScienceEquipment/facility: Facility