TY - JOUR
T1 - Evaluation of [131I]iodoerythronitroimidazole as a predictor for the radiosensitizing effect
AU - Inoue, Tomio
AU - Yang, David J.
AU - Wallace, Sidney
AU - Cherif, Abdallah
AU - Tansey, Wayne
AU - Kim, E. Edmund
AU - Hunter, Nancy
AU - Milross, Christopher G.
AU - Milas, Luka
AU - Podoloff, Donald A.
PY - 1996
Y1 - 1996
N2 - The aim of this study was to evaluate whether radiolabeled iodoerythronitroimidazole (IETNIM) could predict the radiosensitization effect on tumors. Tumor-bearing mice were irradiated at a dose of 25, 31 and 37 Gy after the injection of IETNIM. They were also exposed to 37 Gy radiation at 35, 70, 140 and 240 min after the i.p. injection of IETNIM. After the irradiation, tumor growyh assays were conducted and the effect of IETNIM as a radiosensitizer was estimated as enhancement factor (EF). Tumor uptake was measured at 35, 70, 140 and 240 min after i.p. injection of [131I]IETNIM, which were the same intervals used in the radiosensitization study. EF of IETNIM in mice treated with 25, 30 and 37 Gy irradiation was 0.72, 0.98 and 1.28, respectively. EF of IETNIM in mice irradiated at 35, 70, 140 and 240 min after the injection was 1.50, 1.69, 1.46 and 1.08, which corresponded to the tumor uptake and blood clearance of [131I]IETNIM. [131I]IETNIM may be a suitable radiopharmaceutical to predict the radiosensitization effect of misonidazole analogs on tumors.
AB - The aim of this study was to evaluate whether radiolabeled iodoerythronitroimidazole (IETNIM) could predict the radiosensitization effect on tumors. Tumor-bearing mice were irradiated at a dose of 25, 31 and 37 Gy after the injection of IETNIM. They were also exposed to 37 Gy radiation at 35, 70, 140 and 240 min after the i.p. injection of IETNIM. After the irradiation, tumor growyh assays were conducted and the effect of IETNIM as a radiosensitizer was estimated as enhancement factor (EF). Tumor uptake was measured at 35, 70, 140 and 240 min after i.p. injection of [131I]IETNIM, which were the same intervals used in the radiosensitization study. EF of IETNIM in mice treated with 25, 30 and 37 Gy irradiation was 0.72, 0.98 and 1.28, respectively. EF of IETNIM in mice irradiated at 35, 70, 140 and 240 min after the injection was 1.50, 1.69, 1.46 and 1.08, which corresponded to the tumor uptake and blood clearance of [131I]IETNIM. [131I]IETNIM may be a suitable radiopharmaceutical to predict the radiosensitization effect of misonidazole analogs on tumors.
KW - hypoxic tumor cell
KW - iodoerythronitroimidazole
KW - misonidazole
KW - radiosensitizer
UR - http://www.scopus.com/inward/record.url?scp=10544251445&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=10544251445&partnerID=8YFLogxK
U2 - 10.1097/00001813-199611000-00007
DO - 10.1097/00001813-199611000-00007
M3 - Article
C2 - 8991190
AN - SCOPUS:10544251445
SN - 0959-4973
VL - 7
SP - 858
EP - 865
JO - Anti-cancer drugs
JF - Anti-cancer drugs
IS - 8
ER -