TY - JOUR
T1 - Evaluation, Staging, and Surgical Management for Adrenocortical Carcinoma
T2 - An Update from the SSO Endocrine and Head and Neck Disease Site Working Group
AU - Dickson, Paxton V.
AU - Kim, Lawrence
AU - Yen, Tina W.F.
AU - Yang, Anthony
AU - Grubbs, Elizabeth G.
AU - Patel, Dhavel
AU - Solórzano, Carmen C.
N1 - Publisher Copyright:
© 2018, Society of Surgical Oncology.
PY - 2018/11/1
Y1 - 2018/11/1
N2 - This is the first of a two-part review on adrenocortical carcinoma (ACC), a rare and aggressive malignancy that often presents at an advanced stage. Most patients present with symptoms related to cortisol and/or androgen excess. Appropriate biochemical evaluation and imaging is important in assessing the extent of disease, operative planning, and oncologic surveillance for patients with ACC. For patients with locoregional disease, potential cure requires margin-negative resection, and accumulating evidence suggests that regional lymphadenectomy should be performed. Although laparoscopic adrenalectomy is reported by some to be adequate for localized ACC, open resection in the hands of an experienced adrenal surgeon is the gold standard for operative management of this disease. Cure is rare following disease relapse, however select patients with severe symptoms related to hormone excess or pain may benefit from resection of local or distant recurrence. For best oncologic outcomes, it is recommended that all patients with ACC be treated at centers with multidisciplinary expertise in management of this rare and aggressive malignancy.
AB - This is the first of a two-part review on adrenocortical carcinoma (ACC), a rare and aggressive malignancy that often presents at an advanced stage. Most patients present with symptoms related to cortisol and/or androgen excess. Appropriate biochemical evaluation and imaging is important in assessing the extent of disease, operative planning, and oncologic surveillance for patients with ACC. For patients with locoregional disease, potential cure requires margin-negative resection, and accumulating evidence suggests that regional lymphadenectomy should be performed. Although laparoscopic adrenalectomy is reported by some to be adequate for localized ACC, open resection in the hands of an experienced adrenal surgeon is the gold standard for operative management of this disease. Cure is rare following disease relapse, however select patients with severe symptoms related to hormone excess or pain may benefit from resection of local or distant recurrence. For best oncologic outcomes, it is recommended that all patients with ACC be treated at centers with multidisciplinary expertise in management of this rare and aggressive malignancy.
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U2 - 10.1245/s10434-018-6749-2
DO - 10.1245/s10434-018-6749-2
M3 - Article
C2 - 30229419
AN - SCOPUS:85053523148
SN - 1068-9265
VL - 25
SP - 3460
EP - 3468
JO - Annals of surgical oncology
JF - Annals of surgical oncology
IS - 12
ER -