TY - JOUR
T1 - Evidence of an immune system to brain communication axis that affects central opioid functions
T2 - Muramyl peptides attenuate opiate withdrawal
AU - Dougherty, Patrick M.
AU - Drath, David B.
AU - Dafny, Nachum
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1987/9/11
Y1 - 1987/9/11
N2 - Muramyl peptides are metabolic breakdown products of bacterial cell walls formed in vivo by the reticuloendothelial system. These agents have a variety of immune modulatory and neuropharmacologic effects. It has previously been demonstrated that a variety of immune modifying agents can induce alterations in certain behaviors elicited by opiates. In the present study we investigate possible reciprocal interactions between muramyl dipeptides (MDPs) and central opioid systems using three different experimental models: (1) naloxone-precipitated withdrawal behavior in morphine-dependent rats; (2) the tail immersion assay for determination of morphine-induced antinociception and (3) rectal temperature measurement of the pyrogenic activity of MDP. It is shown that two derivatives of MDP attenuate the severity of naloxone-precipitated withdrawal and morphine-induced antinociception. In addition, it is demonstrated that the pyrogenic activity of a stearoyl derivative of MDP is altered by chronic morphine treatment. These findings suggest both novel neuropharmacologic properties of muramyl dipeptides, as well as demonstrate that yet another immune modifier interacts with centrally mediated opioid phenomena.
AB - Muramyl peptides are metabolic breakdown products of bacterial cell walls formed in vivo by the reticuloendothelial system. These agents have a variety of immune modulatory and neuropharmacologic effects. It has previously been demonstrated that a variety of immune modifying agents can induce alterations in certain behaviors elicited by opiates. In the present study we investigate possible reciprocal interactions between muramyl dipeptides (MDPs) and central opioid systems using three different experimental models: (1) naloxone-precipitated withdrawal behavior in morphine-dependent rats; (2) the tail immersion assay for determination of morphine-induced antinociception and (3) rectal temperature measurement of the pyrogenic activity of MDP. It is shown that two derivatives of MDP attenuate the severity of naloxone-precipitated withdrawal and morphine-induced antinociception. In addition, it is demonstrated that the pyrogenic activity of a stearoyl derivative of MDP is altered by chronic morphine treatment. These findings suggest both novel neuropharmacologic properties of muramyl dipeptides, as well as demonstrate that yet another immune modifier interacts with centrally mediated opioid phenomena.
KW - Immune-brain communication
KW - Muramyl dipeptide
KW - Opiate withdrawal
UR - http://www.scopus.com/inward/record.url?scp=0023267683&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023267683&partnerID=8YFLogxK
U2 - 10.1016/0014-2999(87)90270-6
DO - 10.1016/0014-2999(87)90270-6
M3 - Article
C2 - 2824218
AN - SCOPUS:0023267683
SN - 0014-2999
VL - 141
SP - 253
EP - 260
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 2
ER -