Evolution and Management of Treatment-Related Toxicity in Anal Cancer

Ethan B. Ludmir; Lisa A. Kachnic; Brian G. Czito

doi:10.1016/j.soc.2016.07.004

Evolution and Management of Treatment-Related Toxicity in Anal Cancer

Ethan B. Ludmir, Lisa A. Kachnic, Brian G. Czito

GI Radiation Oncology

Research output: Contribution to journal › Review article › peer-review

16 Scopus citations

Abstract

Over the past several decades, clinical trials have demonstrated improved disease-related outcomes in the definitive treatment of anal cancer. Although treatment with radiation and concurrent chemotherapy results in high rates of cure, significant acute and late toxicities are seen. This review focuses on the evolution of treatment-related toxicity for anal cancer. Management of these adverse effects is reviewed, as are future directions in anal cancer treatment and their impact on toxicity.

Original language	English (US)
Pages (from-to)	91-113
Number of pages	23
Journal	Surgical oncology clinics of North America
Volume	26
Issue number	1
DOIs	https://doi.org/10.1016/j.soc.2016.07.004
State	Published - Jan 1 2017

Keywords

Anal cancer
Chemoradiation
Chemotherapy
Cisplatin
Intensity-modulated radiotherapy
Mitomycin-C
Radiotherapy
Toxicity

ASJC Scopus subject areas

Surgery
Oncology

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title = "Evolution and Management of Treatment-Related Toxicity in Anal Cancer",

abstract = "Over the past several decades, clinical trials have demonstrated improved disease-related outcomes in the definitive treatment of anal cancer. Although treatment with radiation and concurrent chemotherapy results in high rates of cure, significant acute and late toxicities are seen. This review focuses on the evolution of treatment-related toxicity for anal cancer. Management of these adverse effects is reviewed, as are future directions in anal cancer treatment and their impact on toxicity.",

keywords = "Anal cancer, Chemoradiation, Chemotherapy, Cisplatin, Intensity-modulated radiotherapy, Mitomycin-C, Radiotherapy, Toxicity",

author = "Ludmir, {Ethan B.} and Kachnic, {Lisa A.} and Czito, {Brian G.}",

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AU - Ludmir, Ethan B.

AU - Kachnic, Lisa A.

AU - Czito, Brian G.

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Y1 - 2017/1/1

N2 - Over the past several decades, clinical trials have demonstrated improved disease-related outcomes in the definitive treatment of anal cancer. Although treatment with radiation and concurrent chemotherapy results in high rates of cure, significant acute and late toxicities are seen. This review focuses on the evolution of treatment-related toxicity for anal cancer. Management of these adverse effects is reviewed, as are future directions in anal cancer treatment and their impact on toxicity.

AB - Over the past several decades, clinical trials have demonstrated improved disease-related outcomes in the definitive treatment of anal cancer. Although treatment with radiation and concurrent chemotherapy results in high rates of cure, significant acute and late toxicities are seen. This review focuses on the evolution of treatment-related toxicity for anal cancer. Management of these adverse effects is reviewed, as are future directions in anal cancer treatment and their impact on toxicity.

KW - Anal cancer

KW - Chemoradiation

KW - Chemotherapy

KW - Cisplatin

KW - Intensity-modulated radiotherapy

KW - Mitomycin-C

KW - Radiotherapy

KW - Toxicity

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JO - Surgical oncology clinics of North America

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Evolution and Management of Treatment-Related Toxicity in Anal Cancer

Abstract

Keywords

ASJC Scopus subject areas

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