Evolutionary conservation of meiotic DSB proteins: More than just Spo11

Francesca Cole; Scott Keeney; Maria Jasin

doi:10.1101/gad.1944710

Evolutionary conservation of meiotic DSB proteins: More than just Spo11

Francesca Cole, Scott Keeney, Maria Jasin

Research output: Contribution to journal › Review article › peer-review

69 Scopus citations

Abstract

Meiotic recombination is initiated by programmed DNA double-strand breaks (DSBs) generated by the Spo11 protein. In budding yeast, five other meiotic-specific proteins are also required for DSB formation, but, with rare exception, orthologs had not been identified in other species. In this issue of Genes & Development, Kumar and colleagues (pp. 1266-1280) used a phylogenomic approach to identify two of these proteins across multiple clades, and confirmed that one of these, MEI4, is a functional ortholog in mouse.

Original language	English (US)
Pages (from-to)	1201-1207
Number of pages	7
Journal	Genes and Development
Volume	24
Issue number	12
DOIs	https://doi.org/10.1101/gad.1944710
State	Published - Jun 15 2010
Externally published	Yes

Keywords

Double-strand break
Meiosis
Recombination

ASJC Scopus subject areas

Genetics
Developmental Biology

Access to Document

10.1101/gad.1944710

Cite this

@article{5cc828f0e86346f58b98ce2d690f408a,

title = "Evolutionary conservation of meiotic DSB proteins: More than just Spo11",

abstract = "Meiotic recombination is initiated by programmed DNA double-strand breaks (DSBs) generated by the Spo11 protein. In budding yeast, five other meiotic-specific proteins are also required for DSB formation, but, with rare exception, orthologs had not been identified in other species. In this issue of Genes & Development, Kumar and colleagues (pp. 1266-1280) used a phylogenomic approach to identify two of these proteins across multiple clades, and confirmed that one of these, MEI4, is a functional ortholog in mouse.",

keywords = "Double-strand break, Meiosis, Recombination",

author = "Francesca Cole and Scott Keeney and Maria Jasin",

year = "2010",

month = jun,

day = "15",

doi = "10.1101/gad.1944710",

language = "English (US)",

volume = "24",

pages = "1201--1207",

journal = "Genes and Development",

issn = "0890-9369",

publisher = "Cold Spring Harbor Laboratory Press",

number = "12",

}

TY - JOUR

T1 - Evolutionary conservation of meiotic DSB proteins

T2 - More than just Spo11

AU - Cole, Francesca

AU - Keeney, Scott

AU - Jasin, Maria

PY - 2010/6/15

Y1 - 2010/6/15

N2 - Meiotic recombination is initiated by programmed DNA double-strand breaks (DSBs) generated by the Spo11 protein. In budding yeast, five other meiotic-specific proteins are also required for DSB formation, but, with rare exception, orthologs had not been identified in other species. In this issue of Genes & Development, Kumar and colleagues (pp. 1266-1280) used a phylogenomic approach to identify two of these proteins across multiple clades, and confirmed that one of these, MEI4, is a functional ortholog in mouse.

AB - Meiotic recombination is initiated by programmed DNA double-strand breaks (DSBs) generated by the Spo11 protein. In budding yeast, five other meiotic-specific proteins are also required for DSB formation, but, with rare exception, orthologs had not been identified in other species. In this issue of Genes & Development, Kumar and colleagues (pp. 1266-1280) used a phylogenomic approach to identify two of these proteins across multiple clades, and confirmed that one of these, MEI4, is a functional ortholog in mouse.

KW - Double-strand break

KW - Meiosis

KW - Recombination

UR - http://www.scopus.com/inward/record.url?scp=77953925453&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77953925453&partnerID=8YFLogxK

U2 - 10.1101/gad.1944710

DO - 10.1101/gad.1944710

M3 - Review article

C2 - 20551169

AN - SCOPUS:77953925453

SN - 0890-9369

VL - 24

SP - 1201

EP - 1207

JO - Genes and Development

JF - Genes and Development

IS - 12

ER -

Evolutionary conservation of meiotic DSB proteins: More than just Spo11

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this