Exceptionally high payload of doxorubicin in hollow gold nanospheres for near-infrared light-triggered drug release

Jian You; Guodong Zhang; Chun Li

doi:10.1021/nn901181c

Exceptionally high payload of doxorubicin in hollow gold nanospheres for near-infrared light-triggered drug release

Jian You, Guodong Zhang, Chun Li

Cancer Systems Imaging

Research output: Contribution to journal › Article › peer-review

537 Scopus citations

Abstract

We report dual-functional hollow gold nanospheres (HAuNS, ∼40-nm diameter) capable of mediating both photothermal ablation of cancer cells and drug release upon near-infrared (NIR) light irradiation. As high as 63% DOX by weight (∼1.7 μg DOX/μg Au) could be loaded to polyethylene glycol (PEG)-coated HAuNS since DOX was coated to both the outer and the inner surfaces of HAuNS. Irradiation with NIR laser induced photothermal conversion, which triggered rapid DOX release from DOX-loaded HAuNS. The release of DOX was also pH-dependent, with more DOX released in aqueous solution at lower pH. Significantly greater cell killing was observed when MDA-MB-231 cells incubated with DOX-loaded HAuNS were irradiated with NIR light, attributable to both HAuNS-mediated photothermal ablation and cytotoxicity of released free DOX.

Original language	English (US)
Pages (from-to)	1033-1041
Number of pages	9
Journal	ACS Nano
Volume	4
Issue number	2
DOIs	https://doi.org/10.1021/nn901181c
State	Published - Feb 23 2010

Keywords

Doxorubicin
Hollow gold nanospheres
Nearinfrared light. antitumor activity
Triggered release

ASJC Scopus subject areas

General Materials Science
General Engineering
General Physics and Astronomy

MD Anderson CCSG core facilities

Small Animal Imaging Facility

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10.1021/nn901181c

Cite this

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title = "Exceptionally high payload of doxorubicin in hollow gold nanospheres for near-infrared light-triggered drug release",

abstract = "We report dual-functional hollow gold nanospheres (HAuNS, ∼40-nm diameter) capable of mediating both photothermal ablation of cancer cells and drug release upon near-infrared (NIR) light irradiation. As high as 63% DOX by weight (∼1.7 μg DOX/μg Au) could be loaded to polyethylene glycol (PEG)-coated HAuNS since DOX was coated to both the outer and the inner surfaces of HAuNS. Irradiation with NIR laser induced photothermal conversion, which triggered rapid DOX release from DOX-loaded HAuNS. The release of DOX was also pH-dependent, with more DOX released in aqueous solution at lower pH. Significantly greater cell killing was observed when MDA-MB-231 cells incubated with DOX-loaded HAuNS were irradiated with NIR light, attributable to both HAuNS-mediated photothermal ablation and cytotoxicity of released free DOX.",

keywords = "Doxorubicin, Hollow gold nanospheres, Nearinfrared light. antitumor activity, Triggered release",

author = "Jian You and Guodong Zhang and Chun Li",

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AU - You, Jian

AU - Zhang, Guodong

AU - Li, Chun

PY - 2010/2/23

Y1 - 2010/2/23

N2 - We report dual-functional hollow gold nanospheres (HAuNS, ∼40-nm diameter) capable of mediating both photothermal ablation of cancer cells and drug release upon near-infrared (NIR) light irradiation. As high as 63% DOX by weight (∼1.7 μg DOX/μg Au) could be loaded to polyethylene glycol (PEG)-coated HAuNS since DOX was coated to both the outer and the inner surfaces of HAuNS. Irradiation with NIR laser induced photothermal conversion, which triggered rapid DOX release from DOX-loaded HAuNS. The release of DOX was also pH-dependent, with more DOX released in aqueous solution at lower pH. Significantly greater cell killing was observed when MDA-MB-231 cells incubated with DOX-loaded HAuNS were irradiated with NIR light, attributable to both HAuNS-mediated photothermal ablation and cytotoxicity of released free DOX.

AB - We report dual-functional hollow gold nanospheres (HAuNS, ∼40-nm diameter) capable of mediating both photothermal ablation of cancer cells and drug release upon near-infrared (NIR) light irradiation. As high as 63% DOX by weight (∼1.7 μg DOX/μg Au) could be loaded to polyethylene glycol (PEG)-coated HAuNS since DOX was coated to both the outer and the inner surfaces of HAuNS. Irradiation with NIR laser induced photothermal conversion, which triggered rapid DOX release from DOX-loaded HAuNS. The release of DOX was also pH-dependent, with more DOX released in aqueous solution at lower pH. Significantly greater cell killing was observed when MDA-MB-231 cells incubated with DOX-loaded HAuNS were irradiated with NIR light, attributable to both HAuNS-mediated photothermal ablation and cytotoxicity of released free DOX.

KW - Doxorubicin

KW - Hollow gold nanospheres

KW - Nearinfrared light. antitumor activity

KW - Triggered release

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Exceptionally high payload of doxorubicin in hollow gold nanospheres for near-infrared light-triggered drug release

Abstract

Keywords

ASJC Scopus subject areas

MD Anderson CCSG core facilities

Access to Document

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