@article{7a8dfad35e354cc0ae2c2561ba31982b,
title = "Exercise during preoperative therapy increases tumor vascularity in pancreatic tumor patients",
abstract = "The efficacy of chemotherapy is reduced by dysfunctional tumor vasculature, which may limit chemotherapy delivery to tumors. Preclinical studies have shown that moderate aerobic exercise improves tumor vascular function and increases chemotherapy efficacy in mouse models, but the effect of exercise on human tumor vasculature has not yet been determined. Here, we demonstrate that exercise remodels the tumor vasculature, accelerates the regression, and delays the regrowth of pancreatic ductal adenocarcinoma in a patient-derived xenograft mouse model treated with gemcitabine. By evaluating pancreatic adenocarcinoma specimens from patients treated with preoperative chemotherapy or chemoradiation therapy, we also demonstrate for the first time that tumor vascular remodeling occurs in association with exercise in humans. Future studies will evaluate whether exercise-induced vascular remodeling improves gemcitabine or other chemotherapy efficacy in patients, as this study evaluated only changes in tumor vascular structure.",
author = "{Florez Bedoya}, {Claudia Alvarez} and Cardoso, {Ana Carolina Ferreira} and Nathan Parker and An Ngo-Huang and Petzel, {Maria Q.} and Kim, {Michael P.} and David Fogelman and Romero, {Salvador Gabriel} and Huamin Wang and Minjeong Park and Katz, {Matthew H.G.} and Schadler, {Keri L.}",
note = "Funding Information: We gratefully acknowledge the Center for Energy Balance in Cancer Prevention and Survivorship at The University of Texas MD Anderson Cancer Center for providing supportive infrastructure for this work, and the Department of Scientific Publications at The University of Texas MD Anderson Cancer Center for helpful editing. We also gratefully acknowledge Jason Fleming, MD, for establishing the PDX core to allow development of model that was used in this study. This study was supported by the Wyck Knox Jr. Family Foundation; the Center for Energy Balance in Cancer Prevention & Survivorship, Duncan Family Institute for Cancer Prevention and Risk Assessment; the Mike Hogg Foundation; Cancer Prevention & Research Institute of Texas Training Grant/MD Anderson Cancer Prevention Research Training Program (RP170259, Dr. Shine Chang, Principal Investigator); the National Institutes of Health/National Cancer Institute (award 1R21CA218732-01A1); and in part by the National Institutes of Health through Cancer Center Support Grant P30CA016672 (used the histology core resources). Publisher Copyright: {\textcopyright} 2019, The Author(s).",
year = "2019",
month = dec,
day = "1",
doi = "10.1038/s41598-019-49582-3",
language = "English (US)",
volume = "9",
journal = "Scientific reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",
}