TY - JOUR
T1 - Exercise, inflammation, and fatigue in cancer survivors
AU - LaVoy, Emily C.P.
AU - Fagundes, Christopher P.
AU - Dantzer, Robert
N1 - Funding Information:
RD is supported by grants from the National Institute of Neurological Diseases and Stroke of the National Institutes of Health (Grants R01 NS073939; R01 NS074999) and the National Cancer Institute and the National Institute of Mental Health (Grants R01CA193522; R21CA183736).
Publisher Copyright:
Copyright © 2002 by Hinnak Northoff.
PY - 2016
Y1 - 2016
N2 - Cancer-related fatigue significantly disrupts normal functioning and quality of life for a substantial portion of cancer survivors, and may persist for years following cancer treatment. While the causes of persistent fatigue among cancer survivors are not yet fully understood, accumulating evidence suggests that several pathways, including chronic inflammation, autonomic imbalance, HPA-axis dysfunction, and/or mitochondrial damage, could contribute towards the disruption of normal neuronal function and result in the symptom of cancer-related fatigue. Exercise training interventions have been shown to be some of the more successful treatment options to address cancer- related fatigue. In this review, we discuss the literature regarding the causes of persistent fatigue in cancer survivors and the mechanisms by which exercise may relieve this symptom. There is still much work to be done until the prescription of exercise becomes standard practice for cancer survivors. With improvements in the quality of studies, evidenced-based exercise interventions will allow exercise scientists and oncologists to work together to treat cancer-related fatigue.
AB - Cancer-related fatigue significantly disrupts normal functioning and quality of life for a substantial portion of cancer survivors, and may persist for years following cancer treatment. While the causes of persistent fatigue among cancer survivors are not yet fully understood, accumulating evidence suggests that several pathways, including chronic inflammation, autonomic imbalance, HPA-axis dysfunction, and/or mitochondrial damage, could contribute towards the disruption of normal neuronal function and result in the symptom of cancer-related fatigue. Exercise training interventions have been shown to be some of the more successful treatment options to address cancer- related fatigue. In this review, we discuss the literature regarding the causes of persistent fatigue in cancer survivors and the mechanisms by which exercise may relieve this symptom. There is still much work to be done until the prescription of exercise becomes standard practice for cancer survivors. With improvements in the quality of studies, evidenced-based exercise interventions will allow exercise scientists and oncologists to work together to treat cancer-related fatigue.
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M3 - Article
AN - SCOPUS:84983459024
SN - 1077-5552
VL - 22
SP - 82
EP - 92
JO - Exercise Immunology Review
JF - Exercise Immunology Review
ER -