Expanding diversity at the HLA-B locus: 28 Novel HLA-B alleles

A. M. Lazaro, Y. Xiao, Kai Cao, C. Masaberg, L. Nichol, J. Ng, C. K. Hurley, P. E. Posch

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Twenty-eight novel human leukocyte antigen-B alleles are described: one B*07 (*0745), two B*08 (*0826 and *0831), one B*27 (*2731), four B*35 (*350106, *350402, *3566, and *3568), two B*37 (*370102 and *3711), two B*38 (*380102 and *3813), two B*39 (*3935 and *3939), one B*41 (*4108), one B*42 (*4209), two B*44 (*4444 and *4448), two B*48 (*480302 and *4815), one B*51 (*5140), one B*55 (*5523), one B*56 (*5617), two B*57 (*570103 and *5710), and three B*15 (*9505, *9510, and *9519). Sixteen of the variants are single-nucleotide substitutions from their most homologous allele, of which 10 result in amino acid changes (B*0745, *0831, *3813, *3935, *3939, *4815, *9505, *9509, *9510, and *9519) and 6 are silent substitutions. The remaining alleles (B*0826, *2731, *3566, *3568, *3711, *4108, *4209, *4444, *4448, *5140, *5523, *5617, and *5710) differ from their most similar alleles by two to seven nucleotides substitutions, altering from one to five amino acids.

Original languageEnglish (US)
Pages (from-to)471-474
Number of pages4
JournalTissue Antigens
Volume71
Issue number5
DOIs
StatePublished - May 1 2008

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Keywords

  • DNA sequencing
  • Human leukocyte antigen-B

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Genetics

Cite this

Lazaro, A. M., Xiao, Y., Cao, K., Masaberg, C., Nichol, L., Ng, J., Hurley, C. K., & Posch, P. E. (2008). Expanding diversity at the HLA-B locus: 28 Novel HLA-B alleles. Tissue Antigens, 71(5), 471-474. https://doi.org/10.1111/j.1399-0039.2008.01024.x