TY - JOUR
T1 - Experimental animal models of pancreatic carcinogenesis and metastasis.
AU - Wei, Daoyan
AU - Xiong, Henry Q.
AU - Abbruzzese, James L.
AU - Xie, Keping
N1 - Funding Information:
We thank Don Norwood for editorial comments and Judy King for assistance in the preparation of this manuscript. The research work in our laboratory is supported by the Marc Lustgarten Pancreatic Cancer Foundation, Research Project Grant #RPG-00-054-01-CMS from the American Cancer Society, the Physician Referral Service Award, the W. M. Keck Foundation for Cancer Gene Therapy, and Cancer Center Support Core Grant CA 16672-23 from the National Institutes of Health (to K. X.).
PY - 2003
Y1 - 2003
N2 - Pancreatic cancer is a lethal disease characterized by early metastasis, local invasion, and resistance to conventional therapies. To understand its etiology and eventually make prevention of it possible and effective, appropriate carcinogenesis models will certainly help us understand the effects of environmental and genetic elements on pancreatic carcinogenesis. The development of new treatment strategies to control cancer metastasis is of immediate urgency. Fulfillment of this task relies on our knowledge of the cellular and molecular biology of pancreatic cancer metastasis and the availability of biologically and clinically relevant model systems. Many of the existing pancreatic cancer carcinogenesis and metastasis animal models are described in this review. The advantages and disadvantages of each model and their clinical implications are discussed, and special attention is focused on experimental therapeutic strategies targeting pancreatic cancer metastasis.
AB - Pancreatic cancer is a lethal disease characterized by early metastasis, local invasion, and resistance to conventional therapies. To understand its etiology and eventually make prevention of it possible and effective, appropriate carcinogenesis models will certainly help us understand the effects of environmental and genetic elements on pancreatic carcinogenesis. The development of new treatment strategies to control cancer metastasis is of immediate urgency. Fulfillment of this task relies on our knowledge of the cellular and molecular biology of pancreatic cancer metastasis and the availability of biologically and clinically relevant model systems. Many of the existing pancreatic cancer carcinogenesis and metastasis animal models are described in this review. The advantages and disadvantages of each model and their clinical implications are discussed, and special attention is focused on experimental therapeutic strategies targeting pancreatic cancer metastasis.
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U2 - 10.1385/IJGC:33:1:43
DO - 10.1385/IJGC:33:1:43
M3 - Review article
C2 - 12909737
AN - SCOPUS:1542573190
SN - 1537-3649
VL - 33
SP - 43
EP - 60
JO - International Journal of Gastrointestinal Cancer
JF - International Journal of Gastrointestinal Cancer
IS - 1
ER -