TY - JOUR
T1 - Exploiting Molecular and Immune Biology of Gastric and Gastroesophageal Adenocarcinomas to Discover Novel Therapeutic Targets
AU - Elimova, Elena
AU - Song, Shumei
AU - Shimodaira, Yusuke
AU - Lin, Quan
AU - Ajani, Jaffer A.
N1 - Publisher Copyright:
© 2016, Society of Surgical Oncology.
PY - 2016/11/1
Y1 - 2016/11/1
N2 - Gastroesophageal carcinomas (GACs) are a significant problem worldwide, and despite many attempts to improve the outcomes of patients with these tumors, little progress has been made over the last several decades. In the past decade, only transtuzumab and ramucirumab, two drugs with marginal clinical benefit, have been approved for the treatment of patients with GACs. After second-line therapy, most treatment options are generally ineffective. Prior studies in this disease have been largely empiric, using unselected patient populations. More recently, detailed somatic genotyping, enrichment of patients based on biomarkers, and pharmacokinetic studies have opened new avenues for developing treatment options in patients with GAC.
AB - Gastroesophageal carcinomas (GACs) are a significant problem worldwide, and despite many attempts to improve the outcomes of patients with these tumors, little progress has been made over the last several decades. In the past decade, only transtuzumab and ramucirumab, two drugs with marginal clinical benefit, have been approved for the treatment of patients with GACs. After second-line therapy, most treatment options are generally ineffective. Prior studies in this disease have been largely empiric, using unselected patient populations. More recently, detailed somatic genotyping, enrichment of patients based on biomarkers, and pharmacokinetic studies have opened new avenues for developing treatment options in patients with GAC.
UR - http://www.scopus.com/inward/record.url?scp=84981267502&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84981267502&partnerID=8YFLogxK
U2 - 10.1245/s10434-016-5428-4
DO - 10.1245/s10434-016-5428-4
M3 - Article
C2 - 27503493
AN - SCOPUS:84981267502
SN - 1068-9265
VL - 23
SP - 3786
EP - 3791
JO - Annals of surgical oncology
JF - Annals of surgical oncology
IS - 12
ER -