Abstract
Tubulointerstitial fibrosis is a hallmark feature of chronic renal injury. Specific therapies to control the progression of renal fibrosis towards end-stage renal failure are still limited. Transforming growth factor-β1 (TGF-β1) has been identified as a major mediator of renal fibrosis. Recent reports have suggested that Bone Morphogenic Protein-7 (BMP-7), another member of the TGF-β superfamily, accelerates repair of acute renal injury and ameliorates progression of chronic renal fibrosis in a variety of animal models. Interestingly, BMP-7, an endogenous molecule which is present in the normal kidney, vastly decreases its expression during renal injury. Although, the mechanism of BMP-7 action in the kidney is not yet fully understood, the idea of an endogenous molecule with reno-protective function is intriguing.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 217-224 |
| Number of pages | 8 |
| Journal | Histology and histopathology |
| Volume | 18 |
| Issue number | 1 |
| State | Published - Jan 2003 |
| Externally published | Yes |
Keywords
- Bone morphogenic protein-7 (BMP-7)
- Osteogenic protein-1 (OP-1)
- Renal fibrosis
- Transforming growth factor-β1 (TGF-β1)
- Tubular epithelial cells (TECs)
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Histology